3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA

Catalysed by ACAA1

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
2. Gamma-linolenoyl-CoA hydrolase

Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 2 morecytosolOne of 10 routes

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
2. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

Catalysed by ACAA1, ACADL, ACADVL, ACAD9One of 2 routes

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
2. Beta Oxidation of Fatty Acid

Catalysed by ACAA1, ACADM, ACADSmitochondrial matrixOne of 2 routes

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
2. acyl-CoA pool formation and breakdown

Catalysed by ACAA1cytosol

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
2. fatty-acyl-CoA elongation (N-C18:3CoA)

Catalysed by ACAA1, ELOVL4, ELOVL6, ELOVL2 and 1 morecytosolOne of 2 routes

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
2. Gamma-linolenoyl-CoA hydrolase
3. Carnitine O-Palmitoyltransferase

Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosolOne of 244 routes

1. 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CoA = (6Z,9Z,12Z)-octadecatrienoyl-CoA + acetyl-CoA
2. Beta Oxidation of Fatty Acid
3. octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)