hexadecanoyl-CoA

Three steps

• octanoateReach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Beta Oxidation Fatty Acid
  3. Octanoyl-CoA hydrolase

  Catalysed by SCD, SCD5, ACADM, ACADS and 1 moremitochondrial matrix, cytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine
  3. fatty acylamide amidohydrolase

  Catalysed by LPGAT1, PTDSS2, FAAHcytosol

• alpha-linolenic acidReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  3. Utilized Transport

  Catalysed by CPT2, CPT1A, CPT1Bperoxisome, endoplasmic reticulum, cytosol

• phenylacetylglycineReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATL3, GLYATcytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Palmitoleoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 9 morecytosolOne of 7 routes

• elaidic acidReach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Palmitoleoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 11 morecytosolOne of 6 routes

• CHEBI:28666Reach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. LTD4 hydrolysis

  Catalysed by GLYATL3cytosol

• CHEBI:28701Reach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Palmitoleoyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, peroxisomeOne of 7 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by CPT2, CPT1A, CPT1B, CRAT

• a fatty acidReach from here →
  1. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  2. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)

  Catalysed by CERS6, CERS5, CERS2, SGMS1 and 4 moreOne of 2 routes

• Gly-tRNA(Gly)Reach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GLYATL3, GARS1cytosol

• chlorine(.)Reach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  3. Carnitine Transport by Atb0

  Catalysed by CPT2, CPT1A, CPT1B, SLC6A14peroxisome, extracellular space, cytosolOne of 5 routes

• glycocholateReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL3, BAATperoxisomeOne of 3 routes

• (9Z,12Z)-octadecadienoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by PRDX6, LPCAT3, LPCAT1, TAFAZZIN and 13 more

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  3. a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-sn-glycero-3-phosphocholine

  Catalysed by PRDX6, LPCAT3, LPCAT1, PLA2G10 and 13 more

• glutarateReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by CPT2, CPT1A, CPT1B, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylsphinganineReach from here →
  1. L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA
  2. Sphinganine:NADP+ 3-oxidoreductase
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 6 morecytosolOne of 5 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. sphinganine + hexadecanoyl-CoA = N-hexadecanoylsphinganine + CoA + H(+)
  2. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by CERS6, CERS5, CERS2, SGMS1 and 1 more

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
  3. Utilized Transport

  Catalysed by CPT2, CPT1A, CPT1Bperoxisome, endoplasmic reticulum, cytosolOne of 2 routes

• (24S)-hydroxycholesterolReach from here →
  1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  2. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 2 moreOne of 3 routes

• an acylcholineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by PRDX6, LPCAT3, LPCAT1, PLD2 and 2 more

• fatty acidReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. SM pool hydrolysis

  Catalysed by PRDX6, LPCAT3, LPCAT1, SGMS2cytosolOne of 28 routes

• 5-aminolevulinateReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by GLYATL3, ALAS1, ALAS2

• glycochenodeoxycholateReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by GLYATL3, BAAT

• glycochenodeoxycholic acidReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL3, BAATperoxisomeOne of 3 routes

• glyoxylateReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by GLYATL3, AADATOne of 11 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by SCD, SCD5, LPCAT4, LPCAT3 and 2 morecytosol

• sphingosine 1-phosphateReach from here →
  1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  2. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
  3. ATP:sphingosine 1-phosphotransferase

  Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 4 morenucleus, cytosolOne of 2 routes

• glycolithocholic acidReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by GLYATL3, BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GLYATL3, GCATmitochondrial matrix

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PRDX6, LPCAT3, LPCAT1, TAFAZZIN and 1 moreOne of 8 routes

• 25-hydroxycholesterolReach from here →
  1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  2. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
  3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O

  Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 2 moreOne of 4 routes

• all-trans-4-oxoretinolReach from here →
  1. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. cytochrome P450 (retinol)

  Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 4 morecytosol

• 13-cis-retinolReach from here →
  1. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. retinol binding protein (retinol)

  Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 5 morecytosolOne of 3 routes

• N-octanoylsphing-4-enineReach from here →
  1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  2. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
  3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 1 more

• L-ornithineReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by GLYATL3, GATMcytosolOne of 5 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  2. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 2 morenucleus, cytosolOne of 2 routes

• a 1,3-diacylglycerolReach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, MOGAT3 and 3 morecytosolOne of 2 routes

• (24R)-hydroxycholesterolReach from here →
  1. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
  2. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CERS6, TLCD3B, CERS5, CERS2 and 2 more

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GLYATL3, GLDC, GCSHmitochondrial matrix

• taurineReach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Palmitoleoyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• all-trans-13,14-dihydroretinolReach from here →
  1. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
  2. all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)
  3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2

  Catalysed by DGAT1, PNPLA4, AWAT2, MOGAT3 and 4 more

• N-(2-hydroxytetracosanoyl)-sphinganineReach from here →
  1. L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA
  2. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)
  3. 2-hydroxytetracosanoyl-CoA + sphinganine = N-(2-hydroxytetracosanoyl)-sphinganine + CoA + H(+)

  Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 2 more

• an N-acylsphing-4-enineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphate
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by AGPAT2, PLPP1, PLPP3, PLPP2 and 3 moreOne of 15 routes

• N-tetracosanoylsphinganineReach from here →
  1. L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA
  2. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)
  3. tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)

  Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 3 more

• N-hexacosanoylsphinganineReach from here →
  1. L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA
  2. sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)
  3. hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)

  Catalysed by SPTLC1, SPTLC2, SPTLC3, KDSR and 3 more

• O-propanoyl-(R)-carnitineReach from here →
  1. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
  3. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA

  Catalysed by CPT2, CPT1A, CPT1B, CRATOne of 3 routes

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
  2. 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by DGAT1, AWAT2, DGAT2, PNPLA2 and 3 more

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by SCD, SCD5, LPCAT4, LPCAT3 and 1 morecytosol