Compound
sphingosine 1-phosphate
A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Definition from ChEBI (CHEBI:37550), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
10 entities
10 entities reached.
0 reported hops10 assembled from the scaffold
- ABCA1ProteinUNIPROT:O95477transported byInferred only47 paths47 endpoints
- SGPL1ProteinUNIPROT:O95470substrate ofInferred only24 paths12 endpoints
- LPIN2ProteinUNIPROT:Q92539substrate ofInferred only18 paths18 endpoints
- PLPP1ProteinUNIPROT:O14494substrate ofInferred only18 paths9 endpoints
- PLPP2ProteinUNIPROT:O43688substrate ofInferred only18 paths9 endpoints
- LPIN3ProteinUNIPROT:Q9BQK8substrate ofInferred only17 paths17 endpoints
- PLPP3ProteinUNIPROT:O14495substrate ofInferred only16 paths8 endpoints
- SGPP2ProteinUNIPROT:Q8IWX5substrate ofInferred only9 paths9 endpoints
- SGPP1ProteinUNIPROT:Q9BX95substrate ofInferred only9 paths9 endpoints
- ABCC1ProteinUNIPROT:P33527transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
19 statements
19 statements · 1 reference database · Subject: sphingosine 1-phosphate · Sources: Human-GEM
- sphing-4-enine is converted to sphingosine 1-phosphateCompoundHuman-GEM MAR12082Inferred only
- sphingosine 1-phosphate is converted to sphing-4-enineCompoundHuman-GEM MAR00775Inferred only
- sphingosine 1-phosphate is converted to sphing-4-enineCompoundHuman-GEM MAR00783Inferred only
- sphingosine 1-phosphate is converted to sphing-4-enineCompoundHuman-GEM MAR08235Inferred only
- sphing-4-enine is converted to sphingosine 1-phosphateCompoundHuman-GEM MAR00773Inferred only
- sphingosine 1-phosphate is a substrate of LPIN2ProteinHuman-GEM MAR00775Inferred only
- sphingosine 1-phosphate is a substrate of LPIN3ProteinHuman-GEM MAR00775Inferred only
- sphingosine 1-phosphate is a substrate of PLPP1ProteinHuman-GEM MAR00775Inferred only
- sphingosine 1-phosphate is a substrate of PLPP1ProteinHuman-GEM MAR00783Inferred only
- sphingosine 1-phosphate is a substrate of PLPP2ProteinHuman-GEM MAR00783Inferred only
- sphingosine 1-phosphate is a substrate of PLPP2ProteinHuman-GEM MAR00775Inferred only
- sphingosine 1-phosphate is a substrate of PLPP3ProteinHuman-GEM MAR00775Inferred only
Show the remaining 7
- sphingosine 1-phosphate is a substrate of PLPP3ProteinHuman-GEM MAR00783Inferred only
- sphingosine 1-phosphate is a substrate of SGPL1ProteinHuman-GEM MAR08238Inferred only
- sphingosine 1-phosphate is a substrate of SGPL1ProteinHuman-GEM MAR00779Inferred only
- sphingosine 1-phosphate is a substrate of SGPP1ProteinHuman-GEM MAR08235Inferred only
- sphingosine 1-phosphate is a substrate of SGPP2ProteinHuman-GEM MAR00775Inferred only
- sphingosine 1-phosphate is transported by ABCA1ProteinHuman-GEM MAR11802Inferred only
- sphingosine 1-phosphate is transported by ABCC1ProteinHuman-GEM MAR11802Inferred only
Reactions
11 reactions
ATP+sphing-4-enineADP+proton+sphingosine 1-phosphate
Catalysed by SPHK2 or DBP or SPHK1
Reaction pageLeft to rightBalancedEC 2.7.1.91cytosol
Human-GEM MAR00773CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or LPIN2 or LPIN3 or PLPP2 or PLPP3 or SGPP2
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR00775CC BY 4.0Reference data
sphingosine 1-phosphateO-phosphoethanolamine+(2E)-hexadecenal
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27cytosol
Human-GEM MAR00779CC BY 4.0Reference data
sphingosine 1-phosphatesphingosine 1-phosphate
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR00782CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or PLPP2 or PLPP3
Reaction pageLeft to rightBalancedEC 3.1.3.4extracellular space
Human-GEM MAR00783CC BY 4.0Reference data
sphingosine 1-phosphatesphingosine 1-phosphate
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR08234CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by SGPP1
Reaction pageLeft to rightBalancedEC 3.1.3.-endoplasmic reticulum
Human-GEM MAR08235CC BY 4.0Reference data
water+sphingosine 1-phosphateO-phosphoethanolamine+proton+hexadecanoic acid
Catalysed by SGPL1
Reaction pageLeft to rightBalancedEC 4.1.2.27endoplasmic reticulum
Human-GEM MAR08238CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09411CC BY 4.0Reference data
ATP+water+sphingosine 1-phosphateADP+proton+phosphate(3-)+sphingosine 1-phosphate
Reaction pageLeft to rightBalancedEC 7.6.2.2cytosol, extracellular space
Human-GEM MAR11802CC BY 4.0Reference data
ATP+sphing-4-enineADP+proton+sphingosine 1-phosphate
Catalysed by SPHK2
Reaction pageLeft to rightBalancedEC 2.7.1.91nucleus
Human-GEM MAR12082CC BY 4.0Reference data
Other names
9 names
Resolves to: sphingosine 1-phosphate
- Also called
- (2-amino-3-hydroxy-octadec-4-enoxy)phosphonic acid(2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate)C18-Sphingosine 1-phosphateD-erythro-sphingosine 1-phosphateS1PSphing-4-enine 1-phosphateSphingosine 1-phosphic acidsphingosine-1-phosphate
- Systematic name
- (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate