sphingosine 1-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

264 compounds within 3 steps: 4 in 1, 27 in 2, 233 in 3

One step

hexadecanoic acidReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
Catalysed by SGPL1endoplasmic reticulum
O-phosphoethanolamineReach from here →
1. sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)
Catalysed by SGPL1cytosolOne of 2 routes
(2E)-hexadecenalReach from here →
1. sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)
Catalysed by SGPL1cytosol
sphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 2 morecytosolOne of 3 routes

Two steps

(S)-carnitineReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Utilized Transport
Catalysed by SGPL1endoplasmic reticulum, cytosolOne of 2 routes
CHEBI:1146900Reach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
Catalysed by SGPL1endoplasmic reticulum, cytosol
acetaldehydeReach from here →

Three steps

sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)

ethanolamine-phosphate phosphate-lyase (deaminating

Catalysed by SGPL1, ETNPPLcytosol

palmitoyl-CoAReach from here →

Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 3 routes

psychosineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 2 morecytosol

hexadecanalReach from here →

Catalysed by SGPL1cytosolOne of 3 routes

octadecanoateReach from here →

Catalysed by SGPL1endoplasmic reticulum, cytosol

fatty acidReach from here →

Catalysed by SGPL1endoplasmic reticulum, cytosolOne of 4 routes

N-(acetyl)-sphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 morecytosolOne of 2 routes

an N-acylsphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 8 morecytosol

16-hydroxyhexadecanoateReach from here →

Catalysed by SGPL1, CYP4F2, CYP4F3endoplasmic reticulumOne of 2 routes

ethanolamineReach from here →

Catalysed by SGPL1, PHOSPHO1cytosol

CDP-ethanolamineReach from here →

Catalysed by SGPL1, PCYT2cytosol

sphinganine 1-phosphateReach from here →

Catalysed by SGPL1cytosol

sphing-4-enine 1-phosphateReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol

1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 morecytosol

(E)-hexadec-2-enoateReach from here →

Catalysed by SGPL1, ALDH3A2cytosol, endoplasmic reticulumOne of 3 routes

N-dodecanoylsphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 morecytosol

N-tetradecanoylsphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 5 morecytosol

N-hexadecanoylsphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 morecytosolOne of 2 routes

N-octadecanoylsphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 morecytosolOne of 2 routes

N-eicosanoyl-sphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol

N-tetracosanoyl-sphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 morecytosol

N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 5 morecytosol

N-(tetracosenoyl)-sphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 morecytosol

N-(9Z-octadecenoyl)-sphing-4-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 7 morecytosol

sphinga-4E,14Z-dienineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 3 morecytosol

Catalysed by SGPL1, CPT1A, CPT1C, CPT1B

endoplasmic reticulum, cytosol

One of 7 routes

1,2-di-(9Z-hexadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →

Catalysed by SGPL1, PCYT2, CEPT1cytosol

beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 9 morecytosol

an N-acyl-sphinga-4E,14Z-dienineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 9 morecytosol

2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol

sn-glycero-3-phosphoethanolamineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol

2-nonadioyl-sn-glycero-3-phosphocholineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol

N-hexadecanoyl-sphinga-4E,14Z-dienineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 5 morecytosol

(7Z)-octadecenoyl-CoAReach from here →

Catalysed by SGPL1, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 3 routes

CHEBI:15345Reach from here →

Catalysed by SGPL1, AACSendoplasmic reticulum, cytosolOne of 2 routes

cholineReach from here →

Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 morecytosolOne of 2 routes

CHEBI:15380Reach from here →

Catalysed by SGPL1, ALAS1, CPNE7endoplasmic reticulum, cytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Catalysed by SGPL1, GLYAT, GLYATL2, GLYATL1endoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Catalysed by SGPL1, CPT1A, CPT1Bendoplasmic reticulum, cytosolOne of 2 routes

isobutyryl-CoAReach from here →

Catalysed by SGPL1, HADHA, ACAA2, HADHBendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Catalysed by SGPL1, GLYATendoplasmic reticulum, cytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

Catalysed by SGPL1, GLYAT, GLYATL2, GLYATL1endoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 11 routes