a 1-O-alkyl-sn-glycero-3-phosphocholine

Three steps

• arachidonoyl-CoAReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by ENPP2, GDPD1, CHAT, SLC27A2 and 7 morecytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by ENPP2, GDPD1, CHAT, ACAA1 and 2 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by ENPP2, GDPD1, CHAT, SLC27A2 and 7 morecytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by ENPP2, GDPD1, CHAT, CPT1A and 2 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by ENPP2, GDPD1, CHATcytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by ENPP2, GDPD1, CHAT, ACSS3 and 2 morecytosolOne of 43 routes

• L-leucineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• CHEBI:15650Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by ENPP2, GDPD1, CHAT, ZDHHC11B and 31 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ENPP2, GDPD1, CHAT, NAA10cytosol

• CHEBI:15746Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ENPP2, GDPD1, CHAT, SAT1 and 1 morecytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosol

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  3. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)

  Catalysed by LPCAT4, LPCAT2, LPCAT1, CHPT1 and 1 morecytosol

• sulfateReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC26A6extracellular space, cytosol

• 11-cis-retinolReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ENPP2, GDPD1, CHAT, DGAT1 and 4 morecytosol

• cob(II)alaminReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by ENPP2, GDPD1, CHDH, MTRR

• iodideReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC26A4extracellular space, cytosolOne of 23 routes

• L-valineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• oxaloacetateReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by ENPP2, GDPD1, CHAT, ACLYcytosol

• L-arginineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by ENPP2, GDPD1, CHDH, SUOX

• N(2)-acetyl-L-ornithineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by LPCAT4, LPCAT2, LPCAT1, PAFAH1B1 and 5 morecytosol

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by ENPP2, GDPD1, CHDH, RSAD2

• (S)-2-hydroxyglutarateReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by ENPP2, GDPD1, CHDH, L2HGDH

• CHEBI:16856Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, CHAT, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosol

• oxalic acidReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC26A6extracellular space, cytosol

• (R)-3-hydroxybutyric acidReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. transport of (R)-3-hydroxybutanoate and acetate (cytosol to extracellular)

  Catalysed by LPCAT4, LPCAT2, LPCAT1, PAFAH1B1 and 8 morecytosol, extracellular spaceOne of 2 routes

• L-isoleucineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by ENPP2, GDPD1, SLC5A7, CLTRN and 1 moreextracellular space, cytosolOne of 2 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by LPCAT4, LPCAT2, LPCAT1, PAFAH1B1 and 5 morecytosol, endoplasmic reticulum

• anilineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ENPP2, GDPD1, CHAT, NAT2 and 1 morecytosol

• CHEBI:17312Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ENPP2, GDPD1, CHATcytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ENPP2, GDPD1, CHDH, CDK5RAP1One of 4 routes

• L-cysteineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by ENPP2, GDPD1, CHAT, NAGScytosol, mitochondrial matrixOne of 3 routes

• a sphingomyelinReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  3. ceramide cholinephosphotransferase (CDP-choline)

  Catalysed by LPCAT4, LPCAT2, LPCAT1, CHPT1 and 1 morecytosol, endoplasmic reticulum

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by ENPP2, GDPD1, CHDH, DIO1

• 3,3'-diiodo-L-thyronineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by ENPP2, GDPD1, CHDH, DIO1 and 1 moreOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by ENPP2, GDPD1, CHDH, DIO1One of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ENPP2, GDPD1, CHAT, HADHA and 2 morecytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline dehydrogenase (choline)
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by ENPP2, GDPD1, CHDH, ALDH7A1cytosolOne of 7 routes

• 4-methylumbelliferyl acetateReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by LPCAT4, LPCAT2, LPCAT1, PAFAH1B1 and 7 morecytosol

• CHEBI:17895Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosolOne of 2 routes

• CHEBI:17927Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ENPP2, GDPD1, CHATcytosol

• CHEBI:18019Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosol

• L-glutamineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by ENPP2, GDPD1, SLC5A7, SLC6A14extracellular space, cytosol

• CHEBI:18095Reach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by ENPP2, GDPD1, SLC5A7, CLTRN and 1 moreextracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by ENPP2, GDPD1, SLC5A7extracellular space, cytosolOne of 2 routes

• 3',5'-diiodo-L-thyronineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by ENPP2, GDPD1, CHDH, DIO3

• (5Z)-dodecenoyl-CoAReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ENPP2, GDPD1, CHAT, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 3-iodothyronamineReach from here →
  1. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by ENPP2, GDPD1, CHDH, DIO1 and 1 moreOne of 2 routes