L-aspartate

Two steps

• carbamoyl phosphateReach from here →
  1. carbamoyl-phosphate:L-aspartate carbamoyltransferase
  2. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by CADcytosolOne of 4 routes

• adenosine 5'-phosphosulfateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. ATP:sulfate adenylyltransferase

  Catalysed by SLC25A14, SLC25A30, PAPSS1, PAPSS2inner side of the membrane, outer side of the membrane, cytosolOne of 4 routes

• S-methyl-L-methionineReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by SLC7A13, BHMT2inner side of the membrane, outer side of the membrane

• glutathione disulfideReach from here →
  1. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  2. cystine to cysteine conversion

  Catalysed by SLC7A13inner side of the membrane, outer side of the membrane, cytosol

• an acyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 1 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by AGXT2, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

• L-2-aminopentanoateReach from here →
  1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  2. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by AGXT2

• L-2-aminohexanoateReach from here →
  1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  2. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by AGXT2

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)
  2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase

  Catalysed by PAICS, ADSLcytosolOne of 2 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by NAT8L, HADHA, ACAA2, HADHBmitochondrial matrixOne of 3 routes

• N-formyl-L-kynurenineReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC7A13, IDO1, TDO2, IDO2inner side of the membrane, outer side of the membrane

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by NAT8L, SLC27A2, SLC27A5mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC7A13, PPATinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• phosphoenolpyruvateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by GOT2, PCK1, PCK2mitochondrial matrix

• D-glucosamine 6-phosphateReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC7A13, GFPT2, GFPT1inner side of the membrane, outer side of the membrane

• L-methionine (S)-S-oxideReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A13, MSRAinner side of the membrane, outer side of the membrane

• L-methionine (R)-S-oxideReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A13, MSRB3, MSRB1, MSRB2inner side of the membrane, outer side of the membrane

• deoxycholoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by NAT8L, SLC27A2, SLC27A5mitochondrial matrix, cytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC7A13, PAHinner side of the membrane, outer side of the membrane

• L-prolineReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by AGXT2, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SLC25A14, SLC25A30, STSinner side of the membrane, outer side of the membrane

• decanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by NAT8L, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by NAT8L, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

• L-cysteinylglycineReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. gamma-glutamyltransferase (alanine)

  Catalysed by AGXT2, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by NAT8L, CPT1A, CPT1Bmitochondrial matrix, cytosol

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. Transport of 5-Hydroxyindoleacetate

  Catalysed by SLC25A14, SLC25A30, SLC4A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• CHEBI:63544Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 9 routes

• Mo-molybdopterinReach from here →
  1. oxaloacetate + L-alanine = L-aspartate + pyruvate
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by AGXT2, MOCOS

• (2E)-octadecenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by NAT8L, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (2S)-2-aminobutanoateReach from here →
  1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
  2. N(omega),N(omega)-dimethyl-L-arginine + 2-oxobutanoate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + (2S)-2-aminobutanoate

  Catalysed by AGXT2One of 2 routes