S-methylmercury-L-cysteine

Three steps

• Ala-tRNA(Ala)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, AARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycine betaineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• trans-urocanateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of histidine and methionine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by SLC7A8, SLC7A6, HALinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A8, SLC7A5, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:17927Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SLC7A8, NAGSinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:18095Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by SLC7A8, SLC7A5, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC7A8, SLC6A14inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC7A8, SLC7A5, GARTinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC7A8, SLC7A5, PFASinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• ophthalmateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC7A8, SLC7A5, GSSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 2-aminoisobutanoateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC7A8, SLC7A5, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• biocytinReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by SLC7A8, SLC7A7, BTDinner side of the membrane, outer side of the membrane

• 3',5'-diiodo-L-thyronineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO3inner side of the membrane, outer side of the membrane

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. L-Methionine:tRNAMet ligase (AMP-forming)
  3. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase

  Catalysed by SLC7A8, MARS1, MTFMTinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• S-disulfanyl-L-cysteineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC7A8, SLC7A5, CARS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC7A8, NAGS, HADHA, ACAA2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-iodothyronamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO3inner side of the membrane, outer side of the membraneOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO3inner side of the membrane, outer side of the membraneOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO2inner side of the membrane, outer side of the membraneOne of 2 routes

• L-thyronineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO3inner side of the membrane, outer side of the membrane

• thyronamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO3inner side of the membrane, outer side of the membrane

• 3'-iodothyronamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO2inner side of the membrane, outer side of the membraneOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO1, DIO2inner side of the membrane, outer side of the membraneOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO3inner side of the membrane, outer side of the membrane

• 3,3',5'-triiodothyronamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by SLC7A8, CDKAL1, DIO3inner side of the membrane, outer side of the membrane

• L-homocysteine thiolactoneReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + ATP = L-homocysteine thiolactone + AMP + diphosphate

  Catalysed by SLC7A8, BHMT2, MARS1inner side of the membrane, outer side of the membrane

• L-homocysteinyl-AMPReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + ATP + H(+) = L-homocysteinyl-AMP + diphosphate

  Catalysed by SLC7A8, BHMT2, MARS1inner side of the membrane, outer side of the membrane

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC7A8, NAGS, HADHA, ACADVL and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC7A8, NAGS, HADHA, ACADVL and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC7A8, NAGS, ECHS1, ACAA2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC7A8, NAGS, ECHS1, ACAA2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC7A8, SLC7A5, GLYAT, GLYATL2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC7A8, SLC6A14, LPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC12A2, SLC12A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• phenylacetylglycineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC7A8, SLC7A5, GLYATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC7A8, NAGS, ACSM4, ACSM1 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC7A8, SLC7A5, TPH1, TPH2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (2-hydroxyphenyl)acetic acidReach from here →
  1. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)
  2. Phenylalanine Transaminase, Mitochondrial
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by SLC7A8, GOT2, TAT, HPDinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• CHEBI:28666Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• CHEBI:28701Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC7A8, NAGS, ACAA1, SCP2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A8, SLC7A5, SCLYinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. Transport of L-Cystine (L-Leucine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC7A8, SLC7A9, SLC3A1, CTHinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC7A8, SLC7A5, NAGSinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A8, SLC7A5, SLC1A1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by SLC7A8, BCAT2, BCKDHA, BCKDHBinner side of the membrane, outer side of the membrane, mitochondrial matrix

• Cys-tRNA(Cys)Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC7A8, SLC7A5, CARS1inner side of the membrane, outer side of the membrane, extracellular space, cytosol