3,3',5-triiodo-L-thyronine sulfate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

237 compounds within 3 steps: 4 in 1, 44 in 2, 189 in 3

Three steps

CHEBI:1307929Reach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. Steryl-Sulfatase
3. Cholesterol-sulfate sulfohydrolase
Catalysed by STScytosol, Golgi apparatusOne of 4 routes
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)
Catalysed by DIO1, AIFM1, PYROXD1, MOCS1
(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
a quinoneReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of fumarate and sulfate (cytosol to mitochondria)
3. a quinone + succinate = fumarate + a quinol
Catalysed by STS, SLC25A10, SDHBcytosol, mitochondrial matrix
all-trans-3,4-didehydroretinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3,4-didehydroretinol + 2 oxidized [adrenodoxin] + 2 H2O
Catalysed by DIO1, RETSAT, CYP27C1
all-trans-4-hydroxyretinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-4-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O
Catalysed by DIO1, RETSAT, CYP27C1
prostaglandin H3Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
2,4-dinitrophenyl-S-glutathioneReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
Catalysed by STS, SLCO1B1cytosol, extracellular spaceOne of 8 routes
(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS1 and 1 more
2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS2
all-trans-retinyl tetradecanoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA
Catalysed by DIO1, RETSAT, AWAT2
indoxyl sulfateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
3. indoxyl sulfate(out) + a dicarboxylate(in) = indoxyl sulfate(in) + a dicarboxylate(out)
Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
cholineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of chloride and choline (cytosol to extracellular)
Catalysed by STS, SLC26A6, SLC5A7cytosol, extracellular space
pyruvateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of malate and sulfate (cytosol to mitochondria)
3. (S)-malate:NAD+ oxidoreductase (decarboxylating)
Catalysed by STS, SLC25A10, ME2, ME3cytosol, mitochondrial matrixOne of 13 routes
L-leucineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of chloride and leucine (cytosol to extracellular)
Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 7 routes
all-trans-3-hydroxyretinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O
Catalysed by DIO1, RETSAT, CYP27C1
CHEBI:15699Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and homoserine (cytosol to extracellular)
Catalysed by DIO1, MOCOS, SLC7A5extracellular space, cytosolOne of 3 routes
formateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
3. oxalate(in) + formate(out) = oxalate(out) + formate(in)
Catalysed by STS, SLC25A14, SLC26A2, SLC25A30 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 3 routes
nicotinic acid D-ribonucleotideReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. Transport of Quinolinic Acid
3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)
Catalysed by STS, SLC22A6, QPRTcytosol, extracellular space
N-carbamoyl-L-aspartic acidReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
3. carbamoyl-phosphate:L-aspartate carbamoyltransferase
Catalysed by STS, SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane
CHEBI:15971Reach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of chloride and histidine (cytosol to extracellular)
Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 3 routes
methanethiolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
Catalysed by DIO1, KDM1A, KDM1B, SELENBP1
androsteroneReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. steroid sulfatase (androsterone sulfate)
3. steroid sulfatase (androsterone sulfate)
Catalysed by STScytosolOne of 3 routes
L-cystineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
Catalysed by STS, SLC25A14, SLC25A30, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes
11-cis-retinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-Retinol 11-cis-trans-isomerase
Catalysed by DIO1, RETSATcytosolOne of 2 routes
cob(II)alaminReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2
Catalysed by DIO1, AIFM1, PYROXD1, MTRR
17beta-hydroxy-5alpha-androstan-3-oneReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. steroid sulfatase (5-alpha-dihydrotestosterone)
3. steroid sulfatase (5-alpha-dihydrotestosterone)
Catalysed by STScytosolOne of 3 routes
L-citrullineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of citrulline and cysteine (cytosol to extracellular)
Catalysed by DIO1, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes
ubiquinonesReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of fumarate and sulfate (cytosol to mitochondria)
3. succinate:quinone oxidoreductase
Catalysed by STS, SLC25A10, SDHD, SDHB and 2 morecytosol, mitochondrial matrix
L-valineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of chloride and valine (cytosol to extracellular)
Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 7 routes
L-arginineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of arginine and chloride (cytosol to extracellular)
Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 7 routes
nitric oxideReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Catalysed by DIO1, AIFM1, PYROXD1, SUOX
protein polypeptide chainReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
3. PROTEIN_BS
Catalysed by STS, SLC25A14, SLC25A30cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes
pregnenoloneReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. Steryl-Sulfatase
3. Pregnenolone-sulfate sulfohydrolase
Catalysed by STScytosol, Golgi apparatusOne of 4 routes
3'-deoxy-3',4'-didehydro-CTPReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)
Catalysed by DIO1, AIFM1, PYROXD1, RSAD2
(S)-2-hydroxyglutarateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
Catalysed by DIO1, AIFM1, PYROXD1, L2HGDH
3-fumarylpyruvateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of fumarate and sulfate (cytosol to mitochondria)
3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
Catalysed by STS, SLC25A10, FAHD1cytosol, mitochondrial matrix
CHEBI:16856Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. cystine to cysteine conversion
Catalysed by DIO1, MOCOScytosolOne of 5 routes
CHEBI:16857Reach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. Transport of L-Threonine by Atb0 Transporter
Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 5 routes
ferrocytochrome cReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
3. sulfite:ferricytochrome-c oxidoreductase
Catalysed by STS, SLC25A14, SLC25A30, SUOXcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrix
N-acetyl-L-aspartateReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
3. acetyl-CoA:L-aspartate N-acetyltransferase
Catalysed by STS, SLC25A14, SLC25A30, NAT8Lcytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes
L-isoleucineReach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. transport of chloride and isoleucine (cytosol to extracellular)
Catalysed by STS, SLC26A6, SLC6A14cytosol, extracellular spaceOne of 6 routes
CHEBI:17203Reach from here →
1. steroid sulfatase (3,5,3-triiodothyronine-4-sulfate)
2. transport of chloride and sulfate (cytosol to extracellular)
3. Transport of L-Proline by the Apical Imino Amino Acid Transporters
Catalysed by STS, SLC26A6, CLTRN, SLC6A20cytosol, extracellular spaceOne of 6 routes