CHEBI:15765

Three steps

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by DDC, DBH, MAOA, MAOBcytosol

• CHEBI:18095Reach from here →
  1. solute carrier (L-dopa)
  2. transport of alanine and leucine (cytosol to extracellular)
  3. Transport of Hydroxy-Proline

  Catalysed by SLC3A2, SLC7A5, SLC1A4extracellular space, cytosolOne of 5 routes

• N-carbamoyl-beta-alanineReach from here →
  1. solute carrier (L-dopa)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC3A2, SLC7A5, SLC6A14extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC3A2, SLC7A5, GARTextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC3A2, SLC7A5, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. solute carrier (L-dopa)
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC3A2, SLC7A5, PFASextracellular space, cytosol

• (R)-normetanephrineReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by DDC, DBH, COMT, LRTOMTcytosol

• ophthalmateReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC3A2, SLC7A5, GSSextracellular space, cytosol

• 2-aminoisobutanoateReach from here →
  1. solute carrier (L-dopa)
  2. transport of alanine and leucine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC3A2, SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• biocytinReach from here →
  1. solute carrier (L-dopa)
  2. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by SLC3A2, SLC7A5, SLC7A7, BTDextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC3A2, SLC7A5, AGXT2extracellular space, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC3A2, SLC7A5, SHMT1extracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. solute carrier (L-dopa)
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC3A2, SLC7A5, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC3A2, SLC7A5, HADHA, ACAA2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 8 routes

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. sulfotransferase (noradrenaline)

  Catalysed by DDC, DBH, SULT1A3cytosolOne of 2 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC3A2, SLC7A5, HADHA, ACADVL and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC3A2, SLC7A5, HADHA, ACADVL and 1 moreextracellular space, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC3A2, SLC7A5, ECHS1, ACAA2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC3A2, SLC7A5, ECHS1, ACAA2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC3A2, SLC7A5, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• hypochlorous acidReach from here →
  1. solute carrier (L-dopa)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC3A2, SLC7A5, SLC6A14, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. solute carrier (L-dopa)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A5, SLC6A14, SLC12A2 and 1 moreextracellular space, cytosolOne of 3 routes

• 5,6-dihydroxyindoleReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. Peroxidase
  3. peroxidase (dopamine-O-quinone)

  Catalysed by DDC, MPO, TPO, EPX and 1 morecytosol, lysosome

• phenylacetylglycineReach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC3A2, SLC7A5, GLYATextracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC3A2, SLC7A5, ACSM4, ACSM1 and 4 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

• elaidic acidReach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC3A2, SLC7A5, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC3A2, SLC7A5, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by DDC, SLCO1A2, SLCO1B3, GPX5 and 8 morecytosol, extracellular spaceOne of 2 routes

• CHEBI:28666Reach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. transport of LTD4 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1cytosol, extracellular spaceOne of 5 routes

• CHEBI:28701Reach from here →
  1. solute carrier (L-dopa)
  2. Acetylation of Leucine
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC3A2, SLC7A5, ACAA1, SCP2 and 1 moreextracellular space, cytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. solute carrier (L-dopa)
  2. transport of alanine and leucine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC3A2, SLC7A5, SCLYextracellular space, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. solute carrier (L-dopa)
  2. Transport of L-Cystine (L-Leucine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC3A2, SLC7A5, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosol

• CHEBI:28918Reach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

  Catalysed by DDC, DBH, PNMTcytosol

• N-acetyl-L-cysteineReach from here →
  1. solute carrier (L-dopa)
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC3A2, SLC7A5, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosol, mitochondrial matrix

• Cu(2+)Reach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by DDC, DBH, CYBRD1cytosol, inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
  3. a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by DDC, DBH, PAMcytosolOne of 9 routes

• K(+)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC3A2, SLC7A5, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
  1. solute carrier (L-dopa)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)

  Catalysed by SLC3A2, SLC7A5, BCAT2, BCKDHA and 1 moreextracellular space, cytosol, mitochondrial matrix

• Cys-tRNA(Cys)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, GARS1extracellular space, cytosol

• Asp-tRNA(Asp)Reach from here →
  1. solute carrier (L-dopa)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, SLC7A13, DARS1extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• Trp-tRNA(Trp)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of leucine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of isoleucine and leucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of glutamine and leucine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, QARS1extracellular space, cytosol

• isocyanateReach from here →
  1. solute carrier (L-dopa)
  2. transport of citrulline and leucine (cytosol to extracellular)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by SLC3A2, SLC7A5, LACC1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. solute carrier (L-dopa)
  2. transport of asparagine and leucine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC3A2, SLC7A5, NARS1extracellular space, cytosol

• glycocholateReach from here →
  1. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by DDC, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 7 routes