leukotriene F4

Three steps

• L-arginineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by SLC7A6extracellular space, cytosolOne of 7 routes

• CHEBI:16523Reach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• protein polypeptide chainReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. PROTEIN_BS

  No catalyst recordedextracellular space, cytosolOne of 2 routes

• (S)-lactateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLCO2A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 14 routes

• taurochenodeoxycholate 3-sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
  3. taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3 and 1 moreextracellular space, cytosol

• dopamine quinoneReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MPOextracellular space, cytosol, lysosomeOne of 4 routes

• formaldehydeReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 2 moreextracellular space, cytosol

• CHEBI:16857Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 8 routes

• glyoxylic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by DAOcytosol, peroxisome

• (R)-lactaldehydeReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by GLO1, GLOD4, ADH1C, ADH1A and 5 moreextracellular space, cytosol

• L-isoleucineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 8 routes

• CHEBI:17203Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 5 routes

• dehydroascorbic acidReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 19 routes

• estroneReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• anilineReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol

• CHEBI:17312Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosolOne of 2 routes

• sulfiteReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Sulfide:glutathione,quinone oxidoreductase
  3. Persulfide dioxygenase

  Catalysed by SQOR, ETHE1extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• 5-aminolevulinic acidReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ALAS1, ALAS2, CPNE7cytosol, mitochondrial matrix

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 2 moreextracellular space, cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 2 moreextracellular space, cytosolOne of 3 routes

• N-acetylserotoninReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by BHMT, BHMT2extracellular space, cytosol

• urateReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. glutathione:dehydroascorbate oxidoreductase
  3. ascorbate to monodehydroascorbate conversion

  No catalyst recordedextracellular space, cytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• prostaglandin F1Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1B1, DHRS1extracellular space, cytosol

• methylarsonous acidReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

• CHEBI:17895Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 8 routes

• CHEBI:17927Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosol

• butanoateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by SLC7A6extracellular space, cytosolOne of 4 routes

• L-glutamineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 8 routes

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosol

• CHEBI:18183Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by GGT1, GGT5, GGTLC2, GGT6 and 4 moreextracellular space, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GARTcytosol

• arsenic triglutathioneReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 morecytosolOne of 3 routes

• (R)-normetanephrineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, COMT and 1 moreextracellular space, cytosol

• ophthalmateReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GSScytosol

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by MGST3, GSTM4, LTC4S, MGST2cytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 morecytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AGXT2cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Formation of Homocystine
  3. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase

  Catalysed by MTRextracellular space, cytosolOne of 3 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by CARS2extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 2 routes