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Proteins/UNIPROT:P00367
Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. Plays a role in insulin homeostasis. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)..
Function from UniProtKB (P00367), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
71 statements
71 statements · 4 reference databases · Subject: GLUD1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
4 reactions
2-oxoglutarate(2-)+2proton+NADH(2-)+ammoniumL-glutamate(1-)+water+NAD(+)
Reaction pageReversibleBalancedEC 1.4.1.3mitochondrial matrix
Human-GEM MAR03802CC BY 4.0Reference data
2 names
Resolves to: GLUD1
Reaction pageReversibleBalancedEC 1.4.1.3mitochondrial matrix
Human-GEM MAR03804CC BY 4.0Reference data
L-glutamate(1-)+NADP(3-)+water2-oxoglutarate(2-)+ammonium+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:11612CC BY 4.0Reference data
L-glutamate(1-)+NAD(1-)+water2-oxoglutarate(2-)+ammonium+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:15133CC BY 4.0Reference data