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Proteins/UNIPROT:O60716
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors..
Function from UniProtKB (O60716), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
362 statements
362 statements · 4 reference databases · Subject: CTNND1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways · Rows fetched: 300
6 names
Resolves to: CTNND1