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Proteins/UNIPROT:P42575
Is a regulator of the cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress..
[Isoform 1]: Acts as a positive regulator of apoptosis..
[Isoform 2]: Acts as a negative regulator of apoptosis..
[Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death..
Function from UniProtKB (P42575), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
271 statements
271 statements · 4 reference databases · Subject: CASP2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
7 names
Resolves to: CASP2