Loading the page.
Proteins/UNIPROT:Q13232
Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis. In vitro, can also use other phosphate donors such as UTP and GTP. Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization. Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity. Inhibits granulocyte differentiation. May be required for ciliary function during renal development (By similarity)..
Function from UniProtKB (Q13232), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
118 statements
118 statements · 7 reference databases · Subject: NME3 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
31 reactions
5 names
Resolves to: NME3
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04016CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04018CC BY 4.0Reference data
ADP+CHEBI:17677ATP+CHEBI:17239
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04028CC BY 4.0Reference data
ADP+CHEBI:17677ATP+CHEBI:17239
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04030CC BY 4.0Reference data
ADP+CHEBI:16284ATP+CHEBI:16174
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04044CC BY 4.0Reference data
ADP+CHEBI:16039ATP+CHEBI:17808
Catalysed by NME3 or NME4 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04291CC BY 4.0Reference data
ADP+CHEBI:16284ATP+CHEBI:16174
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04420CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04570CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04572CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04635CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04670CC BY 4.0Reference data