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Proteins/UNIPROT:Q9Y234
Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2. In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant (Probable)..
Function from UniProtKB (Q9Y234), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
63 statements
63 statements · 4 reference databases · Subject: LIPT1 · Sources: Hetionet, Reactome, Rhea, WikiPathways
3 reactions
MAM00209mMAM02393m
Catalysed by LIPT1
Reaction pageLeft to rightUnbalancedEC 2.3.1.200mitochondrial matrix
Human-GEM MAR20168CC BY 4.0Reference data
N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein]+L-lysyl-[lipoyl-carrier protein]L-lysyl-[glycine-cleavage complex H protein]+N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]
Catalysed by LIPT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16413CC BY 4.0Reference data
4 names
Resolves to: LIPT1
Catalysed by LIPT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:20473CC BY 4.0Reference data