Proteins/UNIPROT:Q9H6S3

EPS8L2

ProteinUNIPROT:Q9H6S3

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity)..

Function from UniProtKB (Q9H6S3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

hearing loss, autosomal recessive has a germline basis in EPS8L2DiseaseGenCC HGNC:21296|MONDO:0019588Inferred only
hearing loss, autosomal recessive 106 has a germline basis in EPS8L2DiseaseGenCC HGNC:21296|MONDO:0033198Inferred only
nonsyndromic genetic hearing loss has a germline basis in EPS8L2DiseaseGenCC HGNC:21296|MONDO:0019497Inferred only

Statements

20 statements

20 statements · 3 reference databases · Subject: EPS8L2 · Sources: gene ontology, Hetionet, Reactome

Order

APP interacts with EPS8L2ProteinHetionet hetionet:interacts:351-64787Inferred only
CD3E interacts with EPS8L2ProteinHetionet hetionet:interacts:64787-916Inferred only
PTK2 interacts with EPS8L2ProteinHetionet hetionet:interacts:5747-64787Inferred only
RPL23 interacts with EPS8L2ProteinHetionet hetionet:interacts:64787-9349Inferred only
SOS1 interacts with EPS8L2ProteinHetionet hetionet:interacts:64787-6654Inferred only
EPS8L2 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
EPS8L2 participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
EPS8L2 participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
EPS8L2 participates in Sensory processing of sound by outer hair cells of the cochleaPathwayReactome R-HSA-9662361Inferred only
EPS8L2 regulates positive regulation of ruffle assemblyBiological processgene ontology Q9H6S3|GO:1900029Inferred only
EPS8L2 regulates regulation of Rho protein signal transductionBiological processgene ontology Q9H6S3|GO:0035023Inferred only
ABAT increases the expression of EPS8L2ProteinHetionet hetionet:regulates:18-64787Inferred only

Show the remaining 8

AKR7A2 increases the expression of EPS8L2ProteinHetionet hetionet:regulates:8574-64787Inferred only
H2BC12 increases the expression of EPS8L2ProteinHetionet hetionet:regulates:85236-64787Inferred only
HOXC11 increases the expression of EPS8L2ProteinHetionet hetionet:regulates:3227-64787Inferred only
KDELR3 increases the expression of EPS8L2ProteinHetionet hetionet:regulates:11015-64787Inferred only
LRSAM1 decreases the expression of EPS8L2ProteinHetionet hetionet:regulates:90678-64787Inferred only
PAN2 increases the expression of EPS8L2ProteinHetionet hetionet:regulates:9924-64787Inferred only
PPP3CA decreases the expression of EPS8L2ProteinHetionet hetionet:regulates:5530-64787Inferred only
PTPN1 increases the expression of EPS8L2ProteinHetionet hetionet:regulates:5770-64787Inferred only

Other names

4 names

Resolves to: EPS8L2

Also called: Epidermal growth factor receptor pathway substrate 8-related protein 2EPS8-like protein 2EPS8-related protein 2EPS8R2

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