Loading the page.
Proteins/UNIPROT:Q02809
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable)..
Function from UniProtKB (Q02809), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
102 statements
102 statements · 4 reference databases · Subject: PLOD1 · Sources: Hetionet, Reactome, UniProt, WikiPathways
3 reactions
MAM00204c+2-oxoglutarate(2-)+dioxygencarbon dioxide+MAM02767c+succinate(2-)
Catalysed by PLOD1 or PLOD3 or PLOD2
Reaction pageLeft to rightBalance undeterminableEC 1.14.11.4cytosol
Human-GEM MAR06983CC BY 4.0Reference data
2-oxoglutarate(2-)+dioxygen+MAM02768ccarbon dioxide+
4 names
Resolves to: PLOD1
Reaction pageLeft to rightBalance undeterminableEC 1.14.11.4cytosol
Human-GEM MAR09553CC BY 4.0Reference data
L-lysyl-[collagen]+2-oxoglutarate(2-)+dioxygen(5R)-5-hydroxy-L-lysyl-[collagen]+succinate(2-)+carbon dioxide
Catalysed by PLOD2 or PLOD3 or PLOD1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16569CC BY 4.0Reference data