Pathway
MECP2 regulates neuronal receptors and channels
Receptors directly transcriptionally regulated by MECP2 include glutamate receptor GRIA2, NMDA receptor subunits GRIN2A and GRIN2B, opioid receptors OPRK1 and OPRM1, GPRIN1, MET, and NOTCH1. Channels/transporters regulated by MECP2 include TRPC3 and SLC2A3. MECP2 also regulates transcription of FKBP5, involved in trafficking of glucocorticoid receptors and is implicated in regulation of expression of SEMA3F (semaphorin 3F) in mouse olfactory neurons. In zebrafish, Mecp2 is implicated in sensory axon guidance by direct stimulation of transcription of Sema5b and Robo2. MECP2 may indirectly regulate signaling by neuronal receptor tyrosine kinases by regulating transcription of protein tyrosine phosphatases, PTPN1 and PTPN4.
What the reference databases state
Statements
15 statements
15 statements · 1 reference database · Subject: MECP2 regulates neuronal receptors and channels · Sources: Reactome
- FKBP5 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- GPRIN1 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- GRIA2 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- GRIN2A participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- GRIN2B participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- HDAC1 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- HDAC2 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- MET participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- OPRK1 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- OPRM1 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- PTPN1 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- PTPN4 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
Show the remaining 3
- SIN3A participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- SLC2A3 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only
- TRPC3 participates in MECP2 regulates neuronal receptors and channelsProteinReactome R-HSA-9022699Inferred only