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Proteins/UNIPROT:P30279
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals..
Function from UniProtKB (P30279), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
79 statements
79 statements · 4 reference databases · Subject: CCND2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 name
Resolves to: CCND2