Biological process
negative regulation of ERK1 and ERK2 cascade
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
Definition from the Gene Ontology (GO:0070373), read 2026-09-23. CC BY 4.0.
GO:0070373Gene Ontology
What the reference databases state
Statements
63 statements
63 statements · 1 reference database · Subject: negative regulation of ERK1 and ERK2 cascade · Sources: gene ontology
- ACE2 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9BYF1|GO:0070373Inferred only
- ADIPOQ regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q15848|GO:0070373Inferred only
- ATF3 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P18847|GO:0070373Inferred only
- CHRNA10 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9GZZ6|GO:0070373Inferred only
- CHRNA9 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9UGM1|GO:0070373Inferred only
- CNKSR3 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q6P9H4|GO:0070373Inferred only
- CRYBA1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P05813|GO:0070373Inferred only
- CSK regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P41240|GO:0070373Inferred only
- DAB2 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P98082|GO:0070373Inferred only
- DAB2IP regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q5VWQ8|GO:0070373Inferred only
- DLG1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q12959|GO:0070373Inferred only
- DUSP1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P28562|GO:0070373Inferred only
Show the remaining 51
- DUSP10 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9Y6W6|GO:0070373Inferred only
- DUSP26 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9BV47|GO:0070373Inferred only
- DUSP29 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q68J44|GO:0070373Inferred only
- DUSP3 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P51452|GO:0070373Inferred only
- DUSP4 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q13115|GO:0070373Inferred only
- DUSP6 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q16828|GO:0070373Inferred only
- DUSP7 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q16829|GO:0070373Inferred only
- DUSP9 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q99956|GO:0070373Inferred only
- EIF3A regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q14152|GO:0070373Inferred only
- EMILIN1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9Y6C2|GO:0070373Inferred only
- EPHA4 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P54764|GO:0070373Inferred only
- EPHB2 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P29323|GO:0070373Inferred only
- ERRFI1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9UJM3|GO:0070373Inferred only
- EZR regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P15311|GO:0070373Inferred only
- FBLN1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P23142|GO:0070373Inferred only
- FLCN regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q8NFG4|GO:0070373Inferred only
- GBP1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P32455|GO:0070373Inferred only
- GPER1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q99527|GO:0070373Inferred only
- GSTP1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P09211|GO:0070373Inferred only
- ITGB1BP1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O14713|GO:0070373Inferred only
- KLF4 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O43474|GO:0070373Inferred only
- LMO3 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q8TAP4|GO:0070373Inferred only
- LYN regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P07948|GO:0070373Inferred only
- MISO1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q6P1S2|GO:0070373Inferred only
- NHERF1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O14745|GO:0070373Inferred only
- PHB1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P35232|GO:0070373Inferred only
- PIN1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q13526|GO:0070373Inferred only
- PSCA regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O43653|GO:0070373Inferred only
- PTPN1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P18031|GO:0070373Inferred only
- PTPN2 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P17706|GO:0070373Inferred only
- PTPRC regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P08575|GO:0070373Inferred only
- PTPRR regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q15256|GO:0070373Inferred only
- RANBP9 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q96S59|GO:0070373Inferred only
- RGS14 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O43566|GO:0070373Inferred only
- RPS6KA6 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9UK32|GO:0070373Inferred only
- SEMA6A regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9H2E6|GO:0070373Inferred only
- SIRPA regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P78324|GO:0070373Inferred only
- SIRT3 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9NTG7|GO:0070373Inferred only
- SMAD4 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q13485|GO:0070373Inferred only
- SPRED1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q7Z699|GO:0070373Inferred only
- SPRED2 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q7Z698|GO:0070373Inferred only
- SPRED3 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q2MJR0|GO:0070373Inferred only
- SPRY1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O43609|GO:0070373Inferred only
- SPRY2 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O43597|GO:0070373Inferred only
- SPRY3 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O43610|GO:0070373Inferred only
- SPRY4 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9C004|GO:0070373Inferred only
- SYNJ2BP regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P57105|GO:0070373Inferred only
- TLR4 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology O00206|GO:0070373Inferred only
- TNIP1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q15025|GO:0070373Inferred only
- WNK2 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology Q9Y3S1|GO:0070373Inferred only
- XBP1 regulates negative regulation of ERK1 and ERK2 cascadeProteingene ontology P17861|GO:0070373Inferred only