Proteins/UNIPROT:Q5VZ89

DENND4C

ProteinUNIPROT:Q5VZ89

Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin..

Function from UniProtKB (Q5VZ89), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: DENND4C · Sources: gene ontology, Hetionet, Reactome

Order

UBC interacts with DENND4CProteinHetionet hetionet:interacts:55667-7316Inferred only
DENND4C participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
DENND4C participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
DENND4C participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
DENND4C participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
DENND4C regulates regulation of Rab protein signal transductionBiological processgene ontology Q5VZ89|GO:0032483Inferred only
CCNB2 increases the expression of DENND4CProteinHetionet hetionet:regulates:9133-55667Inferred only
ITGAV increases the expression of DENND4CProteinHetionet hetionet:regulates:3685-55667Inferred only
JAZF1 increases the expression of DENND4CProteinHetionet hetionet:regulates:221895-55667Inferred only
PIN1 decreases the expression of DENND4CProteinHetionet hetionet:regulates:5300-55667Inferred only
PRAF2 increases the expression of DENND4CProteinHetionet hetionet:regulates:11230-55667Inferred only
PRKAA1 increases the expression of DENND4CProteinHetionet hetionet:regulates:5562-55667Inferred only

Show the remaining 6

PTPN1 increases the expression of DENND4CProteinHetionet hetionet:regulates:5770-55667Inferred only
STAM2 increases the expression of DENND4CProteinHetionet hetionet:regulates:10254-55667Inferred only
STIL increases the expression of DENND4CProteinHetionet hetionet:regulates:6491-55667Inferred only
TBK1 decreases the expression of DENND4CProteinHetionet hetionet:regulates:29110-55667Inferred only
TRIB1 decreases the expression of DENND4CProteinHetionet hetionet:regulates:10221-55667Inferred only
ZNF517 increases the expression of DENND4CProteinHetionet hetionet:regulates:340385-55667Inferred only

Other names

3 names

Resolves to: DENND4C

Also called: C9orf55C9orf55BDENN domain-containing protein 4C

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