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Proteins/UNIPROT:O95677
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity)..
Function from UniProtKB (O95677), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
11 statements
11 statements · 4 reference databases · Subject: EYA4 · Sources: gene ontology, Hetionet, Reactome, UniProt
1 reaction
1 name
Resolves to: EYA4