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Proteins/UNIPROT:Q86XP1
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization..
Function from UniProtKB (Q86XP1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
52 statements
52 statements · 6 reference databases · Subject: DGKH · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea
3 reactions
3 names
Resolves to: DGKH
a 1,2-diacyl-sn-glycerol+ATP(4-)a 1,2-diacyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10272CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40327CC BY 4.0Reference data