Proteins/UNIPROT:Q96KN8

PLAAT5

ProteinUNIPROT:Q96KN8Phospholipase A and acyltransferase 5

Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs)..

Function from UniProtKB (Q96KN8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 4 reference databases · Subject: PLAAT5 · Sources: Bgee, Hetionet, Reactome, Rhea

Order

LRCOL1 covaries with PLAAT5ProteinHetionet hetionet:covaries:100507055-117245Inferred only
PLAAT5 is expressed in left testisAnatomyBgee ENSG00000168004Inferred only
PLAAT5 is expressed in spermCell typeBgee ENSG00000168004Inferred only
PLAAT5 participates in Acyl chain remodelling of PEPathwayReactome R-HSA-1482839Inferred only
PLAAT5 participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
PLAAT5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PLAAT5 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
PLAAT5 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:45476Inferred only
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:56504Inferred only
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLAAT5CompoundRhea RHEA:56504Inferred only
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLAAT5CompoundRhea RHEA:45172Inferred only

Show the remaining 10

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLAAT5CompoundRhea RHEA:45176Inferred only
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLAAT5CompoundRhea RHEA:45476Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:45172Inferred only
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:45176Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:18689Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:45192Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:45188Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLAAT5CompoundRhea RHEA:15801Inferred only
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine is a substrate of PLAAT5CompoundRhea RHEA:45192Inferred only
a 1,2-diacyl-sn-glycero-3-phosphoethanolamine is a substrate of PLAAT5CompoundRhea RHEA:45188Inferred only

Reactions

8 reactions

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives

Other names

8 names

Resolves to: PLAAT5

Also called: Ca(2+)-independent N-acyltransferaseEC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4H-rev107-like protein 5HRAS-like suppressor 5HRASLS5HRLP5HRSL5iNAT

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Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:15801CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 2-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron

Catalysed by LPL or LIPC or PLAAT3 or PLA2G15 or DDHD1 or ABHD3 or PLAAT5 or PLAAT1 or PNPLA8 or PLAAT2 or PLAAT4 or LIPG