Pathway
Assembly of active LPL and LIPC lipase complexes
Lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (LIPC) enzymes on the lumenal surfaces of capillary endothelia mediate the hydrolysis of triglyceride molecules in circulating lipoprotein particles.
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LPL is widely expressed in the body and is especially abundant in adipocytes and skeletal and cardiac myocytes. Activation of the protein requires glycosylation, dimerization, and glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), which delivers it to heparan sulfate proteoglycan (HSPG) associated with the plasma membrane. It is inactivated by proteolytic cleavage.
Expression of the LPL gene is transcriptionally regulated by Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3), which also regulates the expression of APOA4, APOA5, APOC2, CIDEC and FGF21.
Maturation of LIPC enzyme requires association with LMF1 protein (or possibly, inferred from sequence similarity, LMF2). Heparin binding stabilizes LIPC in its active dimeric form.
What the reference databases state
Statements
18 statements
18 statements · 1 reference database · Subject: Assembly of active LPL and LIPC lipase complexes · Sources: Reactome
- ANGPTL3 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- ANGPTL4 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- ANGPTL8 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- APOA4 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- APOA5 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- APOC2 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- CREB3L3 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- FGF21 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- FURIN participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- GPIHBP1 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- LIPC participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- LMF1 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
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- LMF2 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- LPL participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- MBTPS1 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- MBTPS2 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- PCSK5 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only
- PCSK6 participates in Assembly of active LPL and LIPC lipase complexesProteinReactome R-HSA-8963889Inferred only