Proteins/UNIPROT:Q8TBJ5

FEZF2

ProteinUNIPROT:Q8TBJ5

Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity)..

Function from UniProtKB (Q8TBJ5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

neurodevelopmental disorder has a germline basis in FEZF2DiseaseGenCC HGNC:13506|MONDO:0700092Inferred only

Statements

9 statements

9 statements · 2 reference databases · Subject: FEZF2 · Sources: gene ontology, Hetionet

Order

FEZF2 covaries with CADM4ProteinHetionet hetionet:covaries:199731-55079Inferred only
FEZF2 covaries with CXXC1ProteinHetionet hetionet:covaries:30827-55079Inferred only
SPRY3 covaries with FEZF2ProteinHetionet hetionet:covaries:10251-55079Inferred only
UBL4A covaries with FEZF2ProteinHetionet hetionet:covaries:55079-8266Inferred only
FEZF2 regulates negative regulation of cell population proliferationBiological processgene ontology Q8TBJ5|GO:0008285Inferred only
FEZF2 regulates regulation of gene expressionBiological processgene ontology Q8TBJ5|GO:0010468Inferred only
FEZF2 regulates regulation of neurogenesisBiological processgene ontology Q8TBJ5|GO:0050767Inferred only
FEZF2 increases the expression of EGR1ProteinHetionet hetionet:regulates:55079-1958Inferred only
FEZF2 increases the expression of LPLProteinHetionet hetionet:regulates:55079-4023Inferred only

Other names

5 names

Resolves to: FEZF2

Also called: FEZLForebrain embryonic zinc finger-like protein 2Zinc finger protein 312Zinc finger protein Fez-likeZNF312

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