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Proteins/UNIPROT:P49448
Catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. Plays a key role in glutamate metabolism and energy production via the TCA cycle in neural and testicular tissues. Important for recycling glutamate during neurotransmission (By similarity)..
Function from UniProtKB (P49448), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 2 reference databases · Subject: GLUD2 · Sources: Hetionet, Reactome
4 reactions
2-oxoglutarate(2-)+2proton+NADH(2-)+ammoniumL-glutamate(1-)+water+NAD(+)
Reaction pageReversibleBalancedEC 1.4.1.3mitochondrial matrix
Human-GEM MAR03802CC BY 4.0Reference data
2 names
Resolves to: GLUD2
Reaction pageReversibleBalancedEC 1.4.1.3mitochondrial matrix
Human-GEM MAR03804CC BY 4.0Reference data
L-glutamate(1-)+NADP(3-)+water2-oxoglutarate(2-)+ammonium+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:11612CC BY 4.0Reference data
L-glutamate(1-)+NAD(1-)+water2-oxoglutarate(2-)+ammonium+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:15133CC BY 4.0Reference data