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Proteins/UNIPROT:Q9UL19
Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs)..
Function from UniProtKB (Q9UL19), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
111 statements
111 statements · 5 reference databases · Subject: PLAAT4 · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea
13 reactions
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives
9 names
Resolves to: PLAAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15801CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 2-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by LPL or LIPC or PLAAT3 or PLA2G15 or DDHD1 or ABHD3 or PLAAT5 or PLAAT1 or PNPLA8 or PLAAT2 or PLAAT4 or LIPG
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18689CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PLA2G5 or PLAAT3 or PLB1 or PLA2G4D or PLA2G15 or PLA2G2F or PNPLA8 or PLAAT2 and 4 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:38779CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by DDHD2 or PLAAT3 or PLA2G4F or PLA2G15 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:38783CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water2-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLAAT3 or PLA2G15 or PLAAT1 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:40487CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G4B or PLAAT3 or PNPLA8 or PLAAT2 or PLAAT4 or PLA2G4C
Reaction pageLeft to rightBalanced
Rhea RHEA:40571CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(9Z,12Z)-octadecadienoate+hydron
Catalysed by PLA2G10 or PLA2G1B or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT2 or PLA2G3 or PLA2G2E and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:40815CC BY 4.0Reference data
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+hexadecanoate+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PRDX6 or PLAAT3 or PLB1 or PLA2G15 or PLAAT1 or PLAAT2 or PLA2G2E or PLAAT4 and 2 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:41223CC BY 4.0Reference data
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine+hexadecanoate+hydron
Catalysed by PLAAT3 or PLAAT1 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:41348CC BY 4.0Reference data
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine+water2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine+hexadecanoate+hydron
Catalysed by PLAAT3 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:45164CC BY 4.0Reference data
1-hexanoyl-2-acyl-sn-glycero-3-phosphocholine+waterhexanoate+a 2-acyl-sn-glycero-3-phosphocholine+hydron
Catalysed by PLAAT3 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53496CC BY 4.0Reference data
1,2-diheptadecanoyl-sn-glycero-3-phosphoethanolamine+1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine1,2-diheptadecanoyl-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine+1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+hydron
Catalysed by PLAAT3 or PLAAT2 or PLAAT4
Reaction pageLeft to rightBalanced
Rhea RHEA:53524CC BY 4.0Reference data