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Proteins/UNIPROT:P56211
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression (By similarity)..
Function from UniProtKB (P56211), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
147 statements
147 statements · 3 reference databases · Subject: ARPP19 · Sources: gene ontology, Hetionet, Reactome
2 names
Resolves to: ARPP19