Pathway
Plasma lipoprotein remodeling
As chylomicrons circulate in the body, they acquire molecules of apolipoproteins C and E, and through interaction with endothelial lipases can lose a large fraction of their triacylglycerol. These changes convert them to chylomicron remnants which bind to LDL receptors, primarily on the surfaces of liver cells, clearing them from the circulation. This whole sequence of events is rapid: the normal lifespan of a chylomicron is 30 - 60 minutes.
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As they circulate, VLDL are acted on by lipoprotein lipases on the endothelial surfaces of blood vessels, liberating fatty acids and glycerol to be taken up by tissues and converting the VLDL first to intermediate density lipoproteins (IDL) and then to low density lipoproteins (LDL).
HDL remodeling includes the conversion of HDL-associated cholesterol to cholesterol esters (remodeling of spherical HDL), the transfer of HDL lipids to target cells with the regeneration of pre-beta HDL (lipid-poor apoA-I), and the conversion of pre-beta HDL to discoidal HDL.
What the reference databases state
Statements
32 statements
32 statements · 1 reference database · Subject: Plasma lipoprotein remodeling · Sources: Reactome
- ABCG1 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- ALB participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- ANGPTL3 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- ANGPTL4 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- ANGPTL8 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOA1 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOA2 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOA4 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOA5 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOB participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOC2 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOC3 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
Show the remaining 20
- APOE participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- APOF participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- CETP participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- CREB3L3 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- FGF21 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- FURIN participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- GPIHBP1 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- LCAT participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- LIPC participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- LIPG participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- LMF1 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- LMF2 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- LPA participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- LPL participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- MBTPS1 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- MBTPS2 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- MTTP participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- P4HB participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- PCSK5 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only
- PCSK6 participates in Plasma lipoprotein remodelingProteinReactome R-HSA-8963899Inferred only