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Proteins/UNIPROT:O75477
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex..
(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production..
Function from UniProtKB (O75477), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
45 statements
45 statements · 3 reference databases · Subject: ERLIN1 · Sources: gene ontology, Hetionet, Reactome
8 names
Resolves to: ERLIN1