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Proteins/UNIPROT:Q8WU67

ABHD3

Protein·UNIPROT:Q8WU67Phospholipase ABHD3

Open in the graph

Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids..

Function from UniProtKB (Q8WU67), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

43 statements

43 statements · 4 reference databases · Subject: ABHD3 · Sources: Bgee, Hetionet, Reactome, Rhea

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COX19 covaries with ABHD3ProteinHetionet hetionet:covaries:171586-90639Inferred only
ABHD3 is expressed in jejunal mucosaAnatomyBgee ENSG00000158201Inferred only
ABHD3 is expressed in mucosa of sigmoid colonAnatomyBgee ENSG00000158201Inferred only
ABHD3 is expressed in mucosa of transverse colonAnatomyBgee ENSG00000158201Inferred only
ABHD3 is expressed in rectumAnatomyBgee ENSG00000158201Inferred only
UBC interacts with ABHD3ProteinHetionet hetionet:interacts:171586-7316Inferred only
ABHD3 participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
ABHD3 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
ABHD3 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
ABHD3 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
ABHD3 participates in Synthesis of PCPathwayReactome R-HSA-1483191Inferred only
AFF1 decreases the expression of ABHD3ProteinHetionet hetionet:regulates:4299-171586Inferred only

Show the remaining 31

ARHGDIB decreases the expression of ABHD3ProteinHetionet hetionet:regulates:397-171586Inferred only
DYRK3 increases the expression of ABHD3ProteinHetionet hetionet:regulates:8444-171586Inferred only
EXOSC4 increases the expression of ABHD3ProteinHetionet hetionet:regulates:54512-171586Inferred only
HSF1 increases the expression of ABHD3ProteinHetionet hetionet:regulates:3297-171586Inferred only
NUDCD3 increases the expression of ABHD3ProteinHetionet hetionet:regulates:23386-171586Inferred only
PEPD increases the expression of ABHD3ProteinHetionet hetionet:regulates:5184-171586Inferred only
PPP2R3A decreases the expression of ABHD3ProteinHetionet hetionet:regulates:5523-171586Inferred only
PSMD2 increases the expression of ABHD3ProteinHetionet hetionet:regulates:5708-171586Inferred only
RPTOR decreases the expression of ABHD3ProteinHetionet hetionet:regulates:57521-171586Inferred only
TNFRSF14 increases the expression of ABHD3ProteinHetionet hetionet:regulates:8764-171586Inferred only
USP32 increases the expression of ABHD3ProteinHetionet hetionet:regulates:84669-171586Inferred only
VDAC1 increases the expression of ABHD3ProteinHetionet hetionet:regulates:7416-171586Inferred only
1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:40483Inferred only
1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:41179Inferred only
1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:41159Inferred only
1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:41388Inferred only
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:40479Inferred only
1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54552Inferred only
1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54408Inferred only
1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54464Inferred only
1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54472Inferred only
1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54468Inferred only
1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54460Inferred only
1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54400Inferred only
1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54396Inferred only
1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54392Inferred only
1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54388Inferred only
1,2-ditetradecanoyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54456Inferred only
1,2-ditetradecanoyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:54404Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:18689Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of ABHD3CompoundRhea RHEA:15801Inferred only

Reactions

19 reactions

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron
Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives

Other names

1 name

Resolves to: ABHD3

Also called: Abhydrolase domain-containing protein 3

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Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:15801CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 2-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron

Catalysed by LPL or LIPC or PLAAT3 or PLA2G15 or DDHD1 or ABHD3 or PLAAT5 or PLAAT1 or PNPLA8 or PLAAT2 or PLAAT4 or LIPG

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:18689CC BY 4.0Reference data

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine+water1-O-hexadecyl-sn-glycero-3-phosphocholine+acetate+hydron

Catalysed by PLA2G10 or PLA2G6 or PAFAH1B2 or PLA2G7 or PAFAH1B3 or ABHD3 or PAFAH2

Reaction pageLeft to rightBalanced

Rhea RHEA:40479CC BY 4.0Reference data

1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine+water5-oxopentanoate+1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron

Catalysed by PLA2G7 or ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:40483CC BY 4.0Reference data

1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine+waterglutarate+1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron

Catalysed by PLA2G7 or ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:41159CC BY 4.0Reference data

1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine+water9-oxononanoate+1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron

Catalysed by PLA2G7 or ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:41179CC BY 4.0Reference data

1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine+waternonanedioate+1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron

Catalysed by ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:41388CC BY 4.0Reference data

1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine+water2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine+tetradecanoate+hydron

Catalysed by ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:54388CC BY 4.0Reference data

1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine+water1-tetradecanoyl-sn-glycero-3-phosphocholine+(9Z,12Z)-octadecadienoate+hydron

Catalysed by ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:54392CC BY 4.0Reference data

1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine+tetradecanoate+hydron

Catalysed by ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:54396CC BY 4.0Reference data

1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine+water2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine+tetradecanoate+hydron

Catalysed by ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:54400CC BY 4.0Reference data

1,2-ditetradecanoyl-sn-glycero-3-phosphocholine+water2-tetradecanoyl-sn-glycero-3-phosphocholine+tetradecanoate+hydron

Catalysed by ABHD3

Reaction pageLeft to rightBalanced

Rhea RHEA:54404CC BY 4.0Reference data

Show the remaining 7