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cholesteryl (8Z,11Z,14Z)-eicosatrienoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

219 compounds within 3 steps: 3 in 1, 22 in 2, 194 in 3

Does it reach a compound?

One step

CHEBI:1307929Reach from here →
1. Steryl-ester acylhydrolase
Catalysed by CEL, LIPAlysosomeOne of 2 routes
a cholesterol esterReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
No catalyst recordedendoplasmic reticulumOne of 3 routes
(8Z,11Z,14Z)-eicosatrienoateReach from here →
1. Steryl-ester acylhydrolase
Catalysed by CEL, LIPAlysosomeOne of 2 routes

Two steps

(S)-carnitineReach from here →
1. Steryl-ester acylhydrolase
2. Utilized Transport
Catalysed by CEL, LIPAlysosome, endoplasmic reticulum, cytosol
CHEBI:1146900Reach from here →
1. Steryl-ester acylhydrolase
2. Sterol O-Acyltransferase
Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 60 routes
(22S)-22-hydroxycholesterol

Three steps

(20R,22R)-20,22-dihydroxycholesterolReach from here →
Catalysed by CEL, LIPA, CYP11A1, CYP1B1lysosome, mitochondrial matrix
AReach from here →
Catalysed by

Page 1 of 5

Reach from here →

Steryl-ester acylhydrolase
cytochrome P450 (cholesterol)

Catalysed by CEL, LIPA, CYP11A1, CYP1B1lysosome, mitochondrial matrix

prostaglandin G1Reach from here →

Steryl-ester acylhydrolase
(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

Catalysed by CEL, LIPA, PTGS2lysosome

cholesterol sulfateReach from here →

Steryl-ester acylhydrolase
3'-phosphoadenylyl-sulfate:cholesterol sulfotransferase

Catalysed by CEL, LIPA, SULT2B1, SULT1A3lysosome, cytosolOne of 3 routes

cholesterolReach from here →

cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

Catalysed by CES1, LIPN, NCEH1, LDAHendoplasmic reticulum

pregnenoloneReach from here →

Steryl-ester acylhydrolase
cytochrome P450 (cholesterol)

Catalysed by CEL, LIPA, CYP11A1lysosome, mitochondrial matrix

7alpha-hydroxycholesterolReach from here →

Steryl-ester acylhydrolase
cytochrome P450 (cholesterol)

Catalysed by CEL, LIPA, CYP7A1lysosome, endoplasmic reticulum

1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →

Steryl-ester acylhydrolase
Phosphatidylcholine:sterol O-acyltransferase

Catalysed by CEL, LIPA, LCATlysosome, cytosolOne of 2 routes

desmosterolReach from here →

Steryl-ester acylhydrolase
3-hydroxyacyl-CoA dehydrogenase (desmosterol)

Catalysed by CEL, LIPAlysosome, nucleus

4-methylpentanalReach from here →

Steryl-ester acylhydrolase
cytochrome P450 (cholesterol)

Catalysed by CEL, LIPA, CYP11A1lysosome, mitochondrial matrix

a fatty acidReach from here →

cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

Catalysed by CES1, LIPN, NCEH1, LDAHendoplasmic reticulum

(24S)-hydroxycholesterolReach from here →

Steryl-ester acylhydrolase
Cytochrome P450, Family 46, Subfamily A, Polypeptide 1

Catalysed by CEL, LIPA, CYP46A1lysosome, endoplasmic reticulumOne of 2 routes

fatty acidReach from here →

Steryl-ester acylhydrolase
(10Z)-heptadecenoic acid formation

Catalysed by CEL, LIPAlysosome, cytosolOne of 4 routes

cholesteryl hexadecanoateReach from here →

Steryl-ester acylhydrolase
Acyl-CoA:cholesterol O-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 5 routes

cholesteryl (9Z,12Z)-octadecadienoateReach from here →

Steryl-ester acylhydrolase
Acyl-CoA:cholesterol O-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 5 routes

25-hydroxycholesterolReach from here →

Steryl-ester acylhydrolase
cholesterol 25-hydroxylase (cholesterol)

Catalysed by CEL, LIPA, CH25Hlysosome, endoplasmic reticulum

cholesteryl (9Z-octadecenoate)Reach from here →

Steryl-ester acylhydrolase
Acyl-CoA:cholesterol O-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 5 routes

(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →

Steryl-ester acylhydrolase
long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 6 morelysosome, cytosolOne of 2 routes

(25R)-cholest-5-ene-3beta,26-diolReach from here →

Steryl-ester acylhydrolase
cholesterol,NADPH:oxygen oxidoreductase (5alpha,6alpha-epoxidizing)

Catalysed by CEL, LIPA, CYP27A1lysosome, mitochondrial matrix

cholesteryl octadecanoateReach from here →

Steryl-ester acylhydrolase
Acyl-CoA:cholesterol O-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 5 routes

(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →

Steryl-ester acylhydrolase
Acyl-CoA:cholesterol O-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulumOne of 5 routes

lysosome

One of 2 routes

(5E)-tetradecenoyl-(R)-carnitineReach from here →

Steryl-ester acylhydrolase
Utilized Transport
carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)

Catalysed by CEL, LIPA, CPT1A, CPT1C and 1 morelysosome, endoplasmic reticulum, cytosolOne of 7 routes

pregnenolone sulfateReach from here →

Steryl-ester acylhydrolase
cytochrome P450 (cholesterol)
3'-phosphoadenylyl-sulfate:pregnenolone sulfotransferase

Catalysed by CEL, LIPA, CYP11A1, SULT2B1lysosome, mitochondrial matrix, cytosolOne of 4 routes

(24S)-hydroxycholesterol 24-sulfateReach from here →

Steryl-ester acylhydrolase
Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 24-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by CEL, LIPA, CYP46A1, SULT2A1lysosome, endoplasmic reticulum

(24S)-hydroxycholesterol 3-sulfateReach from here →

Steryl-ester acylhydrolase
Cytochrome P450, Family 46, Subfamily A, Polypeptide 1
(24S)-hydroxycholesterol + 3'-phosphoadenylyl sulfate = (24S)-hydroxycholesterol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by CEL, LIPA, CYP46A1, SULT2B1 and 2 morelysosome, endoplasmic reticulum

a 3-(acyloxy)acyl derivative of bacterial toxinReach from here →

cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

Catalysed by CES1, LIPN, NCEH1, LDAH and 1 moreendoplasmic reticulum

(11Z,14Z,17Z-eicosatrienoyl)-cholesterolReach from here →

cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine

Catalysed by CES1, LIPN, NCEH1, LDAH and 1 moreendoplasmic reticulum

cholesteryl (7Z)-octadecenoateReach from here →

cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

Catalysed by CES1, LIPN, NCEH1, LDAH and 1 moreendoplasmic reticulum

(7Z)-octadecenoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, cytosolOne of 3 routes

CHEBI:15345Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes

cholineReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Acetyl-CoA:choline O-acetyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, nucleus

CHEBI:15380Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
5-aminolevulinate synthase (2-amino-3-oxoadipate)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 2 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
glycine N-acyltransferase (2-methylbutyryl-CoA)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Production of Tiglylcarnitine

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 2 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes

isobutyryl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
glycine-N-acyltransferase (3-methylcrotonoylglycine)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 1 morelysosome, endoplasmic reticulum, mitochondrial matrix

isovaleryl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
glycine N-acyltransferase (isovalerylglycine)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Arachidonate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 13 routes

CHEBI:15519Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
propanoyl-CoA C-acyltransferase

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Palmitate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 8 morelysosome, endoplasmic reticulum, cytosolOne of 11 routes

oleoyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Transport of octadecenoyl-CoA into Mitochondrial Matrix

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, cytosolOne of 11 routes

phenylacetyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Phenylacetate:CoA ligase

Catalysed by CEL, LIPA, SOAT2, SOAT1lysosome, endoplasmic reticulum, cytosolOne of 3 routes

propionyl-CoAReach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
Propanoate:CoA ligase (AMP-forming)

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 3 morelysosome, endoplasmic reticulum, cytosolOne of 45 routes

CHEBI:15650Reach from here →

Steryl-ester acylhydrolase
Sterol O-Acyltransferase
N-acetyl-LTE4 to leukotriene E4 conversion

Catalysed by CEL, LIPA, SOAT2, SOAT1 and 32 morelysosome, endoplasmic reticulum, cytosolOne of 2 routes