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Proteins/UNIPROT:Q8WVB3
Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates..
Function from UniProtKB (Q8WVB3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 3 reference databases · Subject: HEXD · Sources: Hetionet, Human-GEM, WikiPathways
58 reactions
a globoside Gb3Cer (d18:1(4E))+wateralpha-D-galactose+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00804CC BY 4.0Reference data
a globoside Gb4Cer (d18:1(4E))+watera globoside Gb3Cer (d18:1(4E))+MAM02525c
Catalysed by HEXB
5 names
Resolves to: HEXD
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00807CC BY 4.0Reference data
a globoside Gb4Cer (d18:1(4E))+watera globoside Gb3Cer (d18:1(4E))+MAM02525l
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00808CC BY 4.0Reference data
a ganglioside GA2 (d18:1(4E))+watera beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00821CC BY 4.0Reference data
a ganglioside GM2 (d18:1(4E))+watera ganglioside GM3 (d18:1(4E))+MAM02525c
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52cytosol
Human-GEM MAR00828CC BY 4.0Reference data
MAM02013l+waterMAM02012l+a ganglioside GM3 (d18:1(4E))+MAM02525l
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalance undeterminableEC 3.2.1.52lysosome
Human-GEM MAR00836CC BY 4.0Reference data
N,N'-diacetylchitobiose+water2N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR03988CC BY 4.0Reference data
3water+MAM02274lproton+MAM02276l+2N-acetyl-D-glucosamine+sulfate
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07382CC BY 4.0Reference data
2water+MAM02275lMAM02276l+2N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07383CC BY 4.0Reference data
water+MAM02238lMAM02239l+N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07386CC BY 4.0Reference data
2water+MAM02277lproton+MAM02239l+N-acetyl-D-glucosamine+sulfate
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07387CC BY 4.0Reference data
water+MAM02241lMAM02242l+N-acetyl-D-glucosamine
Catalysed by HEXB or HEXD or HEXA
Reaction pageLeft to rightBalancedEC 3.2.1.52lysosome
Human-GEM MAR07390CC BY 4.0Reference data