decanoyl-CoA

Two steps

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by HADHA, ACADVL, HADHBcytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

• octanoateReach from here →
  1. Fatty Acid Beta Oxidation (C10->C8), Peroxisomal
  2. Octanoyl-CoA hydrolase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 7 routes

• elaidic acidReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 7 routes

• decanalReach from here →
  1. Decanoyl-CoA hydrolase
  2. decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+)

  Catalysed by ACOT7, ALDH3A2cytosol

• taurineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by BAATcytosolOne of 2 routes

• glycineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 11 routes

• (R)-methylmalonyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. (S)-methylmalonyl-CoA hydrolase

  No catalyst recordedcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. (2E)-dodecenoyl-CoA formation

  No catalyst recordedcytosol, mitochondrial matrixOne of 8 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Production of Glutaryl Carnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 12 routes

• phytanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. phytanate-CoA ligase

  No catalyst recordedcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 3 morecytosolOne of 15 routes

• sphing-4-enineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by SAT1, SAT2cytosolOne of 3 routes

• L-methionineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by NAGScytosol, mitochondrial matrix

• L-alanineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  No catalyst recordedcytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by NAGScytosol, mitochondrial matrix

• an acyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2cytosol, Golgi apparatusOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SLC27A2, SLC27A5cytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)
  2. N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by GLYATL2, PAM

• (2E)-hexadecenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 11 routes

• (2E)-octenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C10->C8), Peroxisomal
  2. trans-oct-2-enoyl-CoA reductase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome, mitochondrial matrixOne of 5 routes

• 3-oxotetradecanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA

  Catalysed by ELOVL6cytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CPT1A, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes

• 3-oxotetradecasphinganineReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by SPTLC1, SPTLC3cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 8 routes

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMcytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. fatty-acyl-CoA synthase (N-C12:0CoA)
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes