monodehydro-L-ascorbate radical

Three steps

• all-trans-retinyl tetradecanoateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by PAM, GLYATL2, AWAT2

• tetradecyl tetradecanoateReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  3. tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

  Catalysed by PAM, GLYATL2, AWAT2

• N-hexadecanoylglycineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by PAM, GLYATL2, GLYATL3

• octanamideReach from here →
  1. a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by PAM

• (9Z,12Z,15Z)-octadecatrienamideReach from here →
  1. a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. N-(9Z,12Z,15Z)-octadecatrienoylglycine + 2 L-ascorbate + O2 = N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by PAM

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by PAM, GLYATL2, GART

• L-cystine-bis-glycineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by PAM, GLYATL2, DPEP1, DPEP2

• glycyldehydrophenylalanineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by PAM, GLYATL2, DPEP1

• an N-(fatty acyl)-glycineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by PAM, GLYATL2

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by PAM, GLYATL2

• palmitoyl-CoAReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  3. fatty-acyl-CoA synthase (N-C16:0CoA)

  Catalysed by PAM, GLYATL2cytosol

• oleoyl-CoAReach from here →
  1. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. long-chain-fatty-acid-CoA ligase (oleate)

  Catalysed by PAM, FAAH, PM20D1, SLC27A2 and 7 morecytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• L-leucineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by PAM, GLYATL2, GNMTcytosol

• 15(S)-HPETEReach from here →
  1. prostaglandin-F synthase (monodehydroascorbate)
  2. glutathione:dehydroascorbate oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

• CHEBI:15699Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:15971Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and histidine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A6extracellular space, cytosolOne of 2 routes

• ureaReach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. ascorbate to monodehydroascorbate conversion
  3. Peroxidase

  Catalysed by MPOcytosol, nucleusOne of 3 routes

• L-cystineReach from here →
  1. prostaglandin-F synthase (monodehydroascorbate)
  2. glutathione:dehydroascorbate oxidoreductase
  3. cystine to cysteine conversion

  No catalyst recordedcytosol

• L-citrullineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosol

• L-valineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and valine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 4 routes

• L-arginineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of arginine and glycine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A6extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC3A2, SLC7A10extracellular space, cytosolOne of 2 routes

• protein polypeptide chainReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. PROTEIN_BS

  Catalysed by PAM, GLYATL2cytosol

• (S)-lactateReach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. ascorbate to monodehydroascorbate conversion
  3. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)

  Catalysed by SLC22A12, SLC22A13cytosol, inner side of the membrane, outer side of the membrane

• CHEBI:16856Reach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by DBH, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 10 routes

• CHEBI:16857Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and threonine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 4 routes

• glyoxylic acidReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by PAM, GLYATL2, DAOperoxisome

• L-isoleucineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and isoleucine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and proline (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A5, SLC7A6extracellular space, cytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by PAM, GLYATL2, ALAS1, ALAS2 and 1 moremitochondrial matrix

• L-cysteineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 4 routes

• xanthineReach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. ascorbate to monodehydroascorbate conversion
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by XDHcytosolOne of 2 routes

• CHEBI:17895Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:18019Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A6extracellular space, cytosolOne of 2 routes

• L-glutamineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by PAM, GLYATL2, SLC7A5extracellular space, cytosolOne of 4 routes

• 5-hydroxyisourateReach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. ascorbate to monodehydroascorbate conversion
  3. urate:oxygen oxidoreductase

  No catalyst recordedcytosol

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by DBH, MAOA, MAOBcytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PAM, GLYATL2, CROTmitochondrial matrixOne of 4 routes

• dodecanoateReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. Lauroyl-CoA hydrolase

  Catalysed by PAM, GLYATL2, ACOT7, BAAT and 2 morecytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by PAM, GLYATL2, GARTcytosol

• (R)-normetanephrineReach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by DBH, COMT, LRTOMTcytosol

• ophthalmateReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by PAM, GLYATL2, GSS

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by PAM, GLYATL2, AGXT2

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by PAM, GLYATL2, MOGAT2, MOGAT1

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by PAM, GLYATL2, SHMT1cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
  3. stearoyl-CoA 9-desaturase (myristoyl-CoA)

  Catalysed by PAM, GLYATL2, SCD, SCD5cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. 12,13-epoxy-9-hydroperoxy... to 12,13-epoxylinoleic acid-radical conversion
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. sulfotransferase (noradrenaline)

  Catalysed by DBH, SULT1A3cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  2. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by PAM, GLYATL2, GLYAT, GLYATL1mitochondrial matrix