O-acetyl-(R)-carnitine

Three steps

• 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP2C9cytosol, endoplasmic reticulum

• 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. unspecific monooxygenase (arachidonate)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP1A1 and 25 morecytosol, endoplasmic reticulum

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by CPT1A, CPT1C, CPT1B, FAAH and 1 morecytosol, endoplasmic reticulum

• (7Z)-octadecenoyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• CHEBI:15345Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, AACScytosolOne of 2 routes

• cholineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, CHATcytosol, nucleusOne of 2 routes

• CHEBI:15380Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by CPT1A, CPT1C, CPT1B, ALAS1 and 1 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYATcytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 14 routes

• CHEBI:15519Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ACAA1 and 2 morecytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 18 routes

• oleoyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 14 routes

• phenylacetyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• L-leucineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• 12(S)-HPETEReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX12cytosol, endoplasmic reticulumOne of 4 routes

• 15(S)-HPETEReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX15B and 1 morecytosol, endoplasmic reticulumOne of 4 routes

• 5(S)-HPETEReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX5cytosol, endoplasmic reticulum

• CHEBI:15650Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by CPT1A, CPT1C, CPT1B, ZDHHC11B and 31 morecytosolOne of 2 routes

• CHEBI:15727Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAA10cytosol

• CHEBI:15746Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 1 morecytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular space

• sulfateReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 1 morecytosol, extracellular space

• 11-cis-retinolReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 4 morecytosol

• iodideReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 1 morecytosol, extracellular space

• L-valineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• oxaloacetateReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by CPT1A, CPT1C, CPT1B, ACLYcytosol

• L-arginineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:16856Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular space

• oxalic acidReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 1 morecytosol, extracellular space

• L-isoleucineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14 and 2 morecytosol, extracellular spaceOne of 2 routes

• itaconateReach from here →
  1. O-acetyl-(R)-carnitine(in) + (R)-carnitine(out) = O-acetyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by SLC25A20, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• anilineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, NAT2 and 1 morecytosol

• CHEBI:17312Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• 3-hydroxy-3-methylglutarateReach from here →
  1. O-acetyl-(R)-carnitine(in) + (R)-carnitine(out) = O-acetyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by SLC25A20, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• L-cysteineReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrixOne of 3 routes

• hexadecanalReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Utilized Transport
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by CPT1A, CPT1C, CPT1B, ALDH3B1 and 2 morecytosol, endoplasmic reticulumOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by CPT1A, CPT1C, CPT1B, HADHA and 2 morecytosol, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. O-acetyl-(R)-carnitine(in) + (R)-carnitine(out) = O-acetyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLC25A20, SLC22A5, BHMT, BHMT2inner side of the membrane, outer side of the membrane, cytosol

• urateReach from here →
  1. O-acetyl-(R)-carnitine(in) + (R)-carnitine(out) = O-acetyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by SLC25A20, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol

• butanoateReach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC33A1 and 8 morecytosol, mitochondrial matrix

• CHEBI:18019Reach from here →
  1. Acetyl-CoA:carnitine O-acetyltransferase
  2. Carnitine Transport by Atb0
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC6A14cytosol, extracellular space