propanoyl-CoA

Three steps

• L-cysteineReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PCCA, PCCB, NAGSmitochondrial matrix

• indole-3-pyruvateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by CLYBL, AADAT

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PCCA, PCCB, HADHA, ACADVL and 1 moremitochondrial matrix

• glycine betaineReach from here →
  1. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA
  2. O-propanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-propanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by CRAT, SLC25A20, SLC22A5inner side of the membrane, outer side of the membraneOne of 2 routes

• 4-methyl-2-oxopentanoateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by CLYBL, AADAT

• CHEBI:17927Reach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PCCA, PCCBmitochondrial matrix, cytosol

• butanoateReach from here →
  1. propanoyl-CoA + H2O = propanoate + CoA + H(+)
  2. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  3. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

  Catalysed by ACOT8, ACAA2, ACOT9, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-phenylpyruvateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by CLYBL, AADAT

• O-octanoyl-(R)-carnitineReach from here →
  1. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA
  2. O-propanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-propanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  3. octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA

  Catalysed by CRAT, SLC25A20, CPT2, CROTinner side of the membrane, outer side of the membraneOne of 3 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by CLYBL, AGXT2

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by CLYBL, AGXT2

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by CLYBL, AGXT2

• O-butanoyl-(R)-carnitineReach from here →
  1. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA
  2. O-propanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-propanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by CRAT, SLC25A20inner side of the membrane, outer side of the membrane

• (5Z)-dodecenoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PCCA, PCCB, HADHA, ACAA2 and 1 moremitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PCCA, PCCB, HADHA, ACADVL and 1 moremitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PCCA, PCCB, HADHA, ACADVL and 1 moremitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PCCA, PCCB, ECHS1, ACAA2 and 1 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PCCA, PCCB, ECHS1, ACAA2 and 1 moremitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by PCCA, PCCB, ACSM4, ACSM1 and 4 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 5 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. propanoyl-CoA + H2O = propanoate + CoA + H(+)
  2. propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)
  3. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase

  Catalysed by ACOT8, ACAA2, ACOT9, SLC22A9 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• CHEBI:28701Reach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PCCA, PCCB, ACAA1, SCP2 and 1 moremitochondrial matrix, peroxisomeOne of 7 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA
  2. O-propanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-propanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by CRAT, SLC25A20, CPT2inner side of the membrane, outer side of the membrane

• glycolateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by CLYBL, GRHPR

• oxalateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by CLYBL, HAO1

• propionic acidReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. methylmalonyl-CoA decarboxylase
  3. Propanoyl-CoA hydrolase

  Catalysed by PCCA, PCCB, MLYCD, ACOT7cytosolOne of 3 routes

• glutarateReach from here →
  1. propanoyl-CoA + H2O = propanoate + CoA + H(+)
  2. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  3. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by ACOT8, ACAA2, ACOT9, SLC22A9 and 3 moreinner side of the membrane, outer side of the membraneOne of 6 routes

• pentanoateReach from here →
  1. propanoyl-CoA + H2O = propanoate + CoA + H(+)
  2. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)
  3. pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

  Catalysed by ACOT8, ACAA2, ACOT9, SLC22A9inner side of the membrane, outer side of the membraneOne of 4 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by CLYBL, AADAT

• taurineReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PCCA, PCCB, BAATmitochondrial matrix, cytosolOne of 2 routes

• succinyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. Methylmalonyl-CoA epimerase
  3. (R)-methylmalonyl-CoA = succinyl-CoA

  Catalysed by PCCA, PCCB, MCEE, MMUTmitochondrial matrix

• glycineReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PCCA, PCCB, GLYAT, GLYATL2 and 1 moremitochondrial matrixOne of 25 routes

• 3'-dephospho-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PCCA, PCCB, ACP2mitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PCCA, PCCBmitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PCCA, PCCB, ACAA1, MYO5Bmitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PCCA, PCCB, ACSM4, ACSM1 and 4 moremitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Production of Glutaryl Carnitine

  Catalysed by PCCA, PCCB, CPT1A, CPT1C and 1 moremitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PCCA, PCCB, SUCLG1, SUCLG2 and 1 moremitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PCCA, PCCB, CROTmitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. phytanate-CoA ligase

  Catalysed by PCCA, PCCBmitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. propanoyl-CoA + hydrogencarbonate + ATP = (S)-methylmalonyl-CoA + ADP + phosphate + H(+)
  2. (S)-methylmalonyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PCCA, PCCB, SLC27A2, ACSL4 and 5 moremitochondrial matrix, cytosolOne of 15 routes

• 2-oxoadipateReach from here →
  1. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  2. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by CLYBL, AADAT

• O-acetyl-(R)-carnitineReach from here →
  1. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA
  2. O-propanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-propanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  3. (R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA

  Catalysed by CRAT, SLC25A20inner side of the membrane, outer side of the membraneOne of 3 routes