(6Z,9Z,12Z)-octadecatrienoyl-CoA

Two steps

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• octanoateReach from here →
  1. Beta Oxidation of Fatty Acid
  2. Octanoyl-CoA hydrolase

  Catalysed by ACADM, ACADS, ACOT7mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 7 routes

• elaidic acidReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, peroxisomeOne of 7 routes

• an N-acylsphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphingosine N-acyltransferase (sphinganine)

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosol

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by LPCAT4, LPCAT3, LPCAT2, LPCAT1cytosol

• a 1,3-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by MOGAT2, MOGAT3, LPGAT1, TMEM68 and 1 morecytosolOne of 2 routes

• taurineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1cytosol

• glycineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, peroxisomeOne of 2 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. fatty-acyl-CoA elongation (N-C18:3CoA)
  2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by ELOVL4, ELOVL6, ELOVL2, ELOVL5 and 1 morecytosol

• butanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• glutaryl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Production of Glutaryl Carnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 14 routes

• tetradecanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 12 routes

• phytanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. phytanate-CoA ligase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosolOne of 16 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by GNPATcytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPGAT1cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GLYATL3, GLYAT, GLYATL2cytosol

• sphing-4-enineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by LCLAT1, MBOAT7cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMcytosol

• L-alanineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• (3Z)-dodecenoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, GPAT2, LCLAT1 and 9 morecytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 4 routes

• decanoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 8 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Gamma-linolenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 12 routes

• a cardiolipinReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by HADHAcytosol

• (2E)-octenoyl-CoAReach from here →
  1. Beta Oxidation of Fatty Acid
  2. trans-oct-2-enoyl-CoA reductase

  Catalysed by ACADM, ACADS, MECRmitochondrial matrixOne of 5 routes