Loading the page.
Proteins/UNIPROT:Q9NXB9
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators..
Function from UniProtKB (Q9NXB9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
67 statements
67 statements · 5 reference databases · Subject: ELOVL2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
56 reactions
(6Z,9Z,12Z)-octadecatrienoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygencarbon dioxide+CHEBI:1146900+(8Z,11Z,14Z)-eicosatrienoyl-CoA+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
8 names
Resolves to: ELOVL2
Human-GEM MAR00743CC BY 4.0Reference data
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygen(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA+carbon dioxide+CHEBI:1146900+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
Human-GEM MAR00745CC BY 4.0Reference data
arachidonoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygenCHEBI:63544+carbon dioxide+CHEBI:1146900+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
Human-GEM MAR00747CC BY 4.0Reference data
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+5proton+malonyl-CoA+4NADPH(4-)+dioxygen(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA+carbon dioxide+CHEBI:1146900+3water+4NADP(3-)
Catalysed by ELOVL5 or ELOVL4 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.86cytosol
Human-GEM MAR00749CC BY 4.0Reference data
proton+malonyl-CoA+palmitoyl-CoA3-oxooctadecanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02190CC BY 4.0Reference data
proton+malonyl-CoA+octadecanoyl-CoA3-oxoeicosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02201CC BY 4.0Reference data
eicosanoyl-CoA+proton+malonyl-CoA3-oxodocosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02205CC BY 4.0Reference data
docosanoyl-CoA+proton+malonyl-CoA3-oxotetracosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02211CC BY 4.0Reference data
proton+malonyl-CoA+tetracosanoyl-CoA3-oxohexacosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02215CC BY 4.0Reference data
proton+heptadecanoyl-CoA+malonyl-CoAMAM00887c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02259CC BY 4.0Reference data
proton+malonyl-CoA+nonadecanoyl-CoAMAM00873c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02263CC BY 4.0Reference data
proton+MAM02052c+malonyl-CoAMAM00907c+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02267CC BY 4.0Reference data