a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine

Three steps

• acetoneReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 6 morecytosol, extracellular space, mitochondrial matrix

• acetylcholineReach from here →
  1. a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by PAFAH2, ENPP2, GDPD1, CHATcytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and propanoate (cytosol to extracellular)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 8 morecytosol, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular spaceOne of 2 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 5 morecytosol, extracellular spaceOne of 2 routes

• betaine aldehydeReach from here →
  1. a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  3. choline dehydrogenase (choline)

  Catalysed by PAFAH2, ENPP2, GDPD1, CHDHcytosolOne of 3 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate
  3. N-Acetyl-D-glucosamine-6-phosphate amidohydrolase

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 3 morecytosol

• 2-methyl-3-oxopropanoic acidReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space, mitochondrial matrix

• phosphatidic acidReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine phosphatidohydrolase

  Catalysed by CHPT1, CEPT1, PLD2, PLD1 and 1 morecytosolOne of 4 routes

• (17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 3 morecytosol, endoplasmic reticulumOne of 2 routes

• androst-4-ene-3,17-dioneReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 2 morecytosol, endoplasmic reticulumOne of 5 routes

• oxaloacetateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space, mitochondrial matrixOne of 3 routes

• (S)-lactateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 11 morecytosol, extracellular space

• 2-oxobutanoateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of 2-hydroxybutyrate and acetate (cytosol to extracellular)
  3. 2-hydroxybutyrate:NAD+ oxidoreductase

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 9 morecytosol, extracellular spaceOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular spaceOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• sn-glycerol 3-phosphocholineReach from here →
  1. a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-sn-glycero-3-phosphocholine
  2. 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)

  Catalysed by LCAT, PLA2G7, PLA2G6, LYPLA1 and 15 moreOne of 6 routes

• ferrocytochrome cReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 8 morecytosol, extracellular space, mitochondrial matrix

• a cholesterol esterReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. Phosphatidylcholine:sterol O-acyltransferase

  Catalysed by CHPT1, CEPT1, LCATcytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• 4-methylumbelliferoneReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 4 morecytosol

• aceneuramateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• 5'-deoxyadenosineReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 8 morecytosol, extracellular space

• AH2Reach from here →
  1. a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  3. choline + A = betaine aldehyde + AH2

  Catalysed by PAFAH2, ENPP2, GDPD1, CHDH

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulumOne of 8 routes

• urateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 8 morecytosol, extracellular space

• a 1,2-diacyl-sn-glycerolReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2cytosol, Golgi apparatusOne of 4 routes

• a triacylglycerolReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol

  Catalysed by CHPT1, CEPT1, TMEM68cytosol

• all-trans-retinalReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 4 morecytosol, extracellular space

• 4-fumarylacetoacetateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• dTDPReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 8 morecytosol, extracellular space

• CHEBI:18132Reach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. Sphingomyelin cholinephosphohydrolase

  Catalysed by CHPT1, CEPT1, SMPD2, SMPD1 and 3 morecytosol, endoplasmic reticulumOne of 5 routes

• phosphatidyl-L-serineReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylserine synthase (PC-LD pool)

  Catalysed by CHPT1, CEPT1, PTDSS1cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 3 morecytosol, endoplasmic reticulum

• 11-deoxycortisolReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 3 morecytosolOne of 4 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 2 morecytosol, endoplasmic reticulumOne of 6 routes

• a fatty acidReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by CHPT1, CEPT1, PLA2G6, PLA2G4A and 4 morecytosol

• chlorine(.)Reach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 5 morecytosol, extracellular spaceOne of 3 routes

• 3-hydroxypyruvic acidReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular spaceOne of 2 routes

• putrescineReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. N-acetylputrescine + H2O = putrescine + acetate
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 2 morecytosol

• 3-oxopropanoateReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• a phenolReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. a phenyl acetate + H2O = a phenol + acetate + H(+)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 4 morecytosol

• D-serineReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space

• an acylcholineReach from here →
  1. a 1-organyl-2-lyso-sn-glycero-3-phospholipid + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = a 1-organyl-2-acetyl-sn-glycero-3-phospholipid + a 1-O-alkyl-sn-glycero-3-phosphocholine
  2. a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + choline + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by PAFAH2, ENPP2, GDPD1, BCHE

• fatty acidReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulumOne of 6 routes

• (R)-lactic acidReach from here →
  1. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by PAFAH1B1, PAFAH1B2, PAFAH1B3, ASPG and 7 morecytosol, extracellular space