3-hydroxyanthranilate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

112 compounds within 3 steps: 2 in 1, 5 in 2, 105 in 3

Three steps

CHEBI:18019Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. transport of alanine and lysine (cytosol to extracellular)
Catalysed by KYNU, SLC7A6extracellular space, cytosolOne of 4 routes
L-glutamineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. transport of alanine and glutamine (cytosol to extracellular)
Catalysed by KYNU, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 10 routes
CHEBI:18095Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. Transport of Hydroxy-Proline
Catalysed by KYNU, SLC1A4extracellular space, cytosol
N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
Catalysed by KYNU, KYAT3, AADAT, GARTcytosol
ophthalmateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)
Catalysed by KYNU, KYAT3, AADAT, GSS
2-aminoisobutanoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)
Catalysed by KYNU, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes
N(omega),N('omega)-dimethyl-L-arginineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by KYNU, AGXT2One of 2 routes
5,6,7,8-tetrahydrofolic acidReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
Catalysed by KYNU, KYAT3, AADAT, SHMT1cytosolOne of 2 routes
CHEBI:240943Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. glycine N-acyltransferase (2-methylbutyryl-CoA)
Catalysed by KYNU, KYAT3, AADAT, GLYAT and 2 moremitochondrial matrix
phenylacetylglycineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. phenylacetyl-CoA:glycine N-phenylacetyltransferase
Catalysed by KYNU, KYAT3, AADAT, GLYATcytosolOne of 3 routes
CHEBI:28666Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. LTD4 hydrolysis
Catalysed by KYNU, KYAT3, AADATcytosol
pyridoxine 5'-phosphateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. L-selenocysteine selenide-lyase (L-alanine-forming)
Catalysed by KYNU, SCLYcytosol
Gly-tRNA(Gly)Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. glycine:tRNA(Gly) ligase (AMP-forming)
Catalysed by KYNU, KYAT3, AADAT, GARS1cytosol
chlorine(.)Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. transport of alanine and chloride (cytosol to extracellular)
Catalysed by KYNU, SLC6A14extracellular space, cytosolOne of 5 routes
glycocholateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by KYNU, KYAT3, AADAT, BAATperoxisomeOne of 3 routes
L-aspartateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. oxaloacetate + L-alanine = L-aspartate + pyruvate
Catalysed by KYNU, AGXT2
anthranilic acidReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. L-Kynurenine hydrolase
Catalysed by KYNU, KMOcytosol
D-cysteineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)
Catalysed by KYNU, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes
D-serineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
Catalysed by KYNU, SLC7A10inner side of the membrane, outer side of the membraneOne of 6 routes
5-aminolevulinateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Catalysed by KYNU, KYAT3, AADAT, ALAS1 and 1 more
glycochenodeoxycholateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
Catalysed by KYNU, KYAT3, AADAT, BAAT
glycochenodeoxycholic acidReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by KYNU, KYAT3, AADAT, BAATperoxisomeOne of 3 routes
glyoxylateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
Catalysed by KYNU, KYAT3, AADATOne of 11 routes
glycolithocholic acidReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by KYNU, KYAT3, AADAT, BAATcytosolOne of 2 routes
L-2-amino-3-oxobutanoic acidReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by KYNU, KYAT3, AADAT, GCATmitochondrial matrix
L-ornithineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. transport of alanine and ornithine (cytosol to extracellular)
Catalysed by KYNU, SLC7A6extracellular space, cytosolOne of 8 routes
gamma-Glu-AlaReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. gamma-glutamyltransferase (alanine)
Catalysed by KYNU, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol
S(8)-aminomethyldihydrolipoamideReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by KYNU, KYAT3, AADAT, GLDC and 1 moremitochondrial matrix
D-alanineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)
Catalysed by KYNU, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes
sarcosineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by KYNU, KYAT3, AADAT, PIPOXOne of 2 routes
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by KYNU, KYAT3, AADAT, SHMT1 and 1 more
an N-acylglycineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by KYNU, KYAT3, AADAT, GLYATL3 and 2 more
guanidinoacetateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. L-Arginine:glycine amidinotransferase
Catalysed by KYNU, KYAT3, AADAT, GATMcytosolOne of 2 routes
D-threonineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)
Catalysed by KYNU, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes
L-methionineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O
Catalysed by KYNU, KMO, AADATOne of 13 routes
L-tryptophanReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
Catalysed by KYNU, KMO, AADATOne of 10 routes
glutathioneReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by KYNU, KYAT3, AADAT, GSS
L-threonineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
Catalysed by KYNU, SLC7A10inner side of the membrane, outer side of the membraneOne of 4 routes
beta-alanineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)
Catalysed by KYNU, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes
leukotriene C4Reach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. leukotriene C4 hydrolysis
Catalysed by KYNU, KYAT3, AADATcytosol
L-asparagineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. transport of alanine and asparagine (cytosol to extracellular)
Catalysed by KYNU, SLC7A5extracellular space, cytosolOne of 10 routes
L-phenylalanineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. Transport of L-Kynurenine
Catalysed by KYNU, KMO, SLC7A8extracellular space, cytosolOne of 16 routes
L-tyrosineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by KYNU, KYAT3, AADAT
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by KYNU, AGXT2One of 2 routes
trans-4-hydroxy-L-prolineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)
Catalysed by KYNU, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes
L-2-aminopentanoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. 2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O
Catalysed by KYNU, KMO, AADAT
kynurenateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. Kynurenine-Oxoglutarate Transaminase
Catalysed by KYNU, KMO, KYAT3, AADATmitochondrial matrixOne of 13 routes
L-2-aminohexanoateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O
Catalysed by KYNU, KMO, AADAT
N-formyl-L-kynurenineReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)
Catalysed by KYNU, KMO, AFMID
L-2-aminoadipateReach from here →
1. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O
3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
Catalysed by KYNU, KMO, AADAT