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Proteins/UNIPROT:P0DTE5
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone estradiol. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth..
Function from UniProtKB (P0DTE5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 3 reference databases · Subject: UGT2A2 · Sources: Reactome, Rhea, WikiPathways
8 reactions
glucuronate acceptor+UDP-alpha-D-glucuronateacceptor beta-D-glucuronoside+UDP+hydron
Catalysed by UGT1A9 or UGT2B11 or UGT2B17 or UGT2B4 or UGT2A1 or UGT2A2 or UGT2B7 or UGT1A6 or UGT1A1 or UGT1A4 or UGT1A3 or UGT1A5 and 7 more alternatives
1 name
Resolves to: UGT2A2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:21032CC BY 4.0Reference data
17beta-estradiol+UDP-alpha-D-glucuronate17beta-estradiol 3-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT2A1 or UGT2A2 or UGT1A1 or UGT1A3 or UGT1A10 or UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:52460CC BY 4.0Reference data
17alpha-estradiol+UDP-alpha-D-glucuronate17alpha-estradiol 3-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT2B17 or UGT2A1 or UGT2A2 or UGT1A1 or UGT1A3 or UGT2B15 or UGT1A7 or UGT1A10 or UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:52868CC BY 4.0Reference data
chenodeoxycholate+UDP-alpha-D-glucuronatechenodeoxycholoyl-24-O-(beta-D-glucuronate)+UDP
Reaction pageLeft to rightBalanced
Rhea RHEA:52940CC BY 4.0Reference data
deoxycholate+UDP-alpha-D-glucuronatedeoxycholoyl-24-O-(beta-D-glucuronate)+UDP
Catalysed by UGT2A1 or UGT2A2 or UGT1A3
Reaction pageLeft to rightBalanced
Rhea RHEA:52948CC BY 4.0Reference data
lithocholate+UDP-alpha-D-glucuronatelithocholoyl-24-O-(beta-D-glucuronate)+UDP
Catalysed by UGT2A1 or UGT2A2 or UGT1A3
Reaction pageLeft to rightBalanced
Rhea RHEA:52952CC BY 4.0Reference data
hyocholate+UDP-alpha-D-glucuronatehyocholoyl-24-O-(beta-D-glucuronate)+UDP
Catalysed by UGT2A1 or UGT2A2 or UGT1A3
Reaction pageLeft to rightBalanced
Rhea RHEA:52960CC BY 4.0Reference data
hyodeoxycholate+UDP-alpha-D-glucuronatehyodeoxycholate 6-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT2A2 or UGT2B7 or UGT2A3
Reaction pageLeft to rightBalanced
Rhea RHEA:52964CC BY 4.0Reference data