S-methylmercury-L-cysteine

Three steps

• (3Z)-dodecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by SLC7A8, NAGS, HADHA, ACAA2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLC7A8, SLC7A5, CARS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC7A8, SLC7A5, IDO1, TDO2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-2-aminoadipateReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. Transport of L-Kynurenine
  3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

  Catalysed by SLC7A8, SLC43A1, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SLC7A8, NAGS, SLC27A2, SLC27A5inner side of the membrane, outer side of the membrane, mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• 5-phospho-beta-D-ribosylamineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC7A8, SLC7A5, PPATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC7A8, SLC7A5, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by SLC7A8, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• deoxycholoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SLC7A8, NAGS, SLC27A2, SLC27A5inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLC7A8, SLC7A5, PPCSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A8, PAH, TPH1, TPH2inner side of the membrane, outer side of the membraneOne of 3 routes

• 2-hydroxy-4-methylvaleric acidReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. L-Leucine:2-oxoglutarate aminotransferase
  3. 4-methyl-2-oxopentanoate reduction

  Catalysed by SLC7A8, BCAT2, SDR42E2, AKR1B15 and 16 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• an L-alpha-amino acidReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. Transport of L-Kynurenine
  3. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

  Catalysed by SLC7A8, SLC43A1, SLC7A11inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 4-aminobutanoateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of chloride and methionine (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC7A8, SLC7A5, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• dopamineReach from here →
  1. S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)
  2. solute carrier (L-dopa)
  3. 3,4-Dihydroxy-L-phenylalanine carboxy-lyase

  Catalysed by SLC7A8, SLC3A2, SLC7A5, DDCinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC7A8, SLC7A5, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N-benzoylglycineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of cysteine and methionine (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by SLC7A8, SLC7A5, CDO1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• decanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by SLC7A8, NAGS, ACSM4, ACSM1 and 4 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SLC7A8, NAGS, CPT1A, CPT1C and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 11 routes

• L-cysteinylglycineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by SLC7A8, SLC7A5, GGTLC3, GGT1 and 4 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by SLC7A8, NAGS, CPT1A, CPT1Binner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• CHEBI:63544Reach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 9 routes

• a 2,3-saturated acyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by SLC7A8, CDKAL1, ACAD10inner side of the membrane, outer side of the membrane

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by SLC7A8, SLC7A6, NOS3, NOS1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of alanine and methionine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC7A8, SLC7A5, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by SLC7A8, NAGS, CPT1A, CPT1C and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 8 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by SLC7A8, NAGS, SLC27A2, ACSL4 and 6 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• (2S)-2-aminobutanoateReach from here →
  1. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes