2-hydroxy-4-methylvaleric acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

63 compounds within 3 steps: 1 in 1, 5 in 2, 57 in 3

One step

4-methyl-2-oxopentanoateReach from here →
1. 4-methyl-2-oxopentanoate reduction
Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 14 morecytosol

Two steps

L-leucineReach from here →
1. 4-methyl-2-oxopentanoate reduction
2. 4-methyl-2-oxopentanoate + L-kynurenine = kynurenate + L-leucine + H2O
Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosolOne of 2 routes
3-methyl-1-hydroxybutylthiamine diphosphateReach from here →
1. 4-methyl-2-oxopentanoate reduction
2. branched chain keto acid dehydrogenase E1 (4-methyl-2-oxopentanoate)
Catalysed by SDR42E2, AKR1B15, AKR1B10, and 16 more

Three steps

ADH5

cytosol, mitochondrial matrix

glyoxylateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol

3-hydroxyisovaleric acidReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

kynurenateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 more

cytosol

N-octanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

N-decanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

N-dodecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

N-tetradecanoyl-(2S)-hydroxyglycineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

kinetensinReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 17 morecytosol

(S)-malateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

CHEBI:15699Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 3 routes

CHEBI:15765Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 17 morecytosol, extracellular space

CHEBI:15971Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 2 routes

L-cystineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 17 morecytosol, extracellular space

L-citrullineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol, extracellular spaceOne of 2 routes

L-valineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 4 routes

L-arginineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 18 morecytosol, extracellular spaceOne of 6 routes

protein polypeptide chainReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol

4-methylsulfanyl-2-oxobutanoateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol

2-oxobutanoateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

CHEBI:16857Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 4 routes

L-isoleucineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 3 routes

CHEBI:17203Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 3 routes

L-cysteineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 17 morecytosol, extracellular spaceOne of 3 routes

indole-3-pyruvateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol

CHEBI:17895Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 4 routes

3-phenylpyruvateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol

CHEBI:18019Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 2 routes

L-glutamineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 4 routes

S-methylmercury-L-cysteineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

5-(3-methylguanidino)-2-oxopentanoateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

a dicarboxylateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

chlorine(.)Reach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 2 routes

glycolateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

L-aspartateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

oxalateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol

glutarateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

L-lysineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

3-(4-hydroxyphenyl)pyruvateReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 15 morecytosol

L-ornithineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 4 routes

glycineReach from here →

Catalysed by SDR42E2, AKR1B15, AKR1B10, ADH5 and 16 morecytosol, extracellular spaceOne of 20 routes