CHEBI:18095

Three steps

• 3,3'-diiodo-L-thyronineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by SLC1A4, MOCOS, DIO1, DIO3extracellular space, cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Steryl-Sulfatase

  Catalysed by CLTRN, SLC6A20, SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 4 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLC1A4, HADHA, ACADVL, HADHBextracellular space, cytosol, mitochondrial matrix

• CHEBI:17724Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of betaine and chloride (cytosol to extracellular)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A12, BHMT and 1 moreextracellular space, cytosol

• trans-urocanateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, HALextracellular space, cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by CLTRN, SLC6A20, SLC6A14, TPH1 and 1 moreextracellular space, cytosol

• 4-methyl-2-oxopentanoateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by CLTRN, SLC6A20, SLC6A14, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 4 routes

• CHEBI:17927Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of arginine and chloride (cytosol to extracellular)
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC3A2 and 1 moreextracellular space, cytosolOne of 2 routes

• 3-oxopropanoic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by CLTRN, SLC6A20, SLC6A6, SLC6A14 and 1 moreextracellular space, cytosol, mitochondrial matrix

• 3-phenylpyruvateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by CLTRN, SLC6A20, SLC6A14, GOT2 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
  3. a quinone + succinate = fumarate + a quinol

  Catalysed by PYCR1, PYCR3, PYCR2, PRODH2 and 1 morecytosolOne of 3 routes

• dTDPReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. pyruvate kinase (dTDP)

  Catalysed by SLC1A4, AGXT2, PKM, PKLRextracellular space, cytosol, mitochondrial matrix

• O-octanoyl-(R)-carnitineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. solute carrier (L-carnitine)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC25A20extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. ATP:choline phosphotransferase

  Catalysed by CLTRN, SLC6A20, SLC5A7, CHKA and 1 moreextracellular space, cytosol

• CHEBI:18183Reach from here →
  1. Transport of Hydroxy-Proline
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by SLC1A4, GGT1, GGT5, GGTLC2 and 5 moreextracellular space, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• 2-phenylethylamineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, DDCextracellular space, cytosol

• CHEBI:18405Reach from here →
  1. Transport of Hydroxy-Proline
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. pyridoxine 5'-phosphate:oxygen oxidoreductase

  Catalysed by SLC1A4, SCLY, PNPOextracellular space, cytosolOne of 3 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by CLTRN, SLC6A20, SLC6A14, PFASextracellular space, cytosol

• gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)

  Catalysed by SLC1A4, AGXT2, GCLCextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by CLTRN, SLC6A20, SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• D-isoleucineReach from here →
  1. Transport of Hydroxy-Proline
  2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by SLC1A4, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• Xaa-L-Pro dipeptideReach from here →
  1. Transport of Hydroxy-Proline
  2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)
  3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

  Catalysed by SLC1A4, PEPDextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 3',5'-diiodo-L-thyronineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by SLC1A4, MOCOS, DIO3extracellular space, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC1A4, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC1A4, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. Transport of Hydroxy-Proline
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC1A4, AGXT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 2 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by CLTRN, SLC6A20, SLC6A14, CARS2extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC1A4, HADHA, ACAA2, HADHBextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-iodothyronamineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by SLC1A4, MOCOS, DIO1, DIO3extracellular space, cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by SLC1A4, MOCOS, DIO1, DIO3extracellular space, cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC1A4, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosol, mitochondrial matrixOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by SLC1A4, MOCOS, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• L-thyronineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by SLC1A4, MOCOS, DIO3extracellular space, cytosol

• thyronamineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by SLC1A4, MOCOS, DIO3extracellular space, cytosol

• 3'-iodothyronamineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by SLC1A4, MOCOS, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC1A4, MOCOS, DIO1, DIO2extracellular space, cytosolOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC1A4, MOCOS, DIO3extracellular space, cytosol

• 3,3',5'-triiodothyronamineReach from here →
  1. Transport of Hydroxy-Proline
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by SLC1A4, MOCOS, DIO3extracellular space, cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC1A4, HADHA, ACADVL, HADHBextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC1A4, HADHA, ACADVL, HADHBextracellular space, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC1A4, ECHS1, ACAA2, HADHextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Transport of Hydroxy-Proline
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC1A4, ECHS1, ACAA2, HADHextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• a quinolReach from here →
  1. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase
  2. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
  3. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

  Catalysed by PYCR1, PYCR3, PYCR2, PRODH2 and 2 morecytosol, outer side of the membraneOne of 14 routes

• alpha-linolenic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by CLTRN, SLC6A20, SLC6A14extracellular space, cytosol, endoplasmic reticulum

• folic acidReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by CLTRN, SLC6A20, SLC26A6, SLC22A8 and 1 moreextracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by CLTRN, SLC6A20, SLC6A9, SLC6A14 and 1 moreextracellular space, cytosolOne of 3 routes