sulfite

Two steps

• aceneuramateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by MPST, TST, NPLcytosol

• 5'-deoxyadenosineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by MPST, TST, TYW1B, TYW1cytosol

• enol-oxaloacetateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC25A10, SDHB, SDHAmitochondrial matrix, cytosol

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Steryl-Sulfatase

  Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• urateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by TSTD1, SLC22A13inner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by TSTD1, GSTO1, GSTO2

• thiocyanateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. thiosulfate:cyanide sulfurtranserase

  Catalysed by MPST, TSTcytosol, mitochondrial matrixOne of 5 routes

• 4-fumarylacetoacetateReach from here →
  1. transport of fumarate and sulfite (cytosol to mitochondria)
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SLC25A10, FAHmitochondrial matrix, cytosol

• dTDPReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. pyruvate kinase (dTDP)

  Catalysed by MPST, TST, PKM, PKLRcytosol

• arsenic triglutathioneReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by TSTD1, AS3MTOne of 3 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by TSTD1, MGST3

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX1, GPX4

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by TSTD1, GPX4

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2cytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by TSTD1, GSTP1

• a quinolReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by SLC25A10, SDHB, SDHAmitochondrial matrix, cytosolOne of 2 routes

• folic acidReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. Folate Transport by Oats

  Catalysed by SUOX, SLC22A8, SLC22A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• a dicarboxylateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A35, SLC25A34mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-ascorbic acidReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by TSTD1, CLIC1, GSTO1, GSTO2

• chlorine(.)Reach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• cholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by MPST, TSTcytosolOne of 3 routes

• D-aspartateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

• oxalateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC26A2, SLC25A30 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 3 morecytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• citric acidReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Citrate Transport, Mitochondrial

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 5 routes

• butyric acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 2 routes

• maleateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-hydroxypyruvic acidReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. L-Serine:pyruvate aminotransferase

  Catalysed by MPST, TST, AGXTcytosolOne of 2 routes

• an alcoholReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by TSTD1, CP, PRDX6

• isocitric acidReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• (2R,3R)-tartrateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. sulfite:ferricytochrome-c oxidoreductase
  2. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by SLC25A10, SLC25A1mitochondrial matrix, cytosolOne of 3 routes

• 3-oxopropanoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by MPST, TST, AGXT2cytosol

• D-serineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. D-serine = pyruvate + NH4(+)

  Catalysed by MPST, TST, SRRcytosol

• glycochenodeoxycholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  2. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• glyoxylateReach from here →
  1. transport of malate and sulfite (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by SLC25A10, CLYBLmitochondrial matrix, cytosol