CHEBI:15650

Two steps

• CHEBI:27540Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 5 routes

• 5(S)-HETEReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28701Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, peroxisomeOne of 7 routes

• glycocholateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (glycocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• cholateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• serotoninReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• chenodeoxycholateReach from here →
  1. transport of leukotriene E4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• taurocholateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (GSH)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholic acidReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• gamma-Glu-AlaReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO1B1, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

• taurineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 12 routes

• (R)-methylmalonyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 34 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Production of Glutaryl Carnitine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. phytanate-CoA ligase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 35 morecytosolOne of 15 routes

• prostaglandin E1Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosol

• leukotriene A4Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by SLCO1B1, GLO1, GLOD4extracellular space, cytosolOne of 2 routes

• S-formylglutathioneReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)

  Catalysed by SLCO1B1, ADH1C, ADH1A, ADH5 and 3 moreextracellular space, cytosol

• sphing-4-enineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• dehydroepiandrosterone 3-sulfateReach from here →
  1. transport of leukotriene E4 (cytosol to extracellular)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosol, mitochondrial matrix

• leukotriene C4Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. leukotriene C4 synthase (GSH)

  Catalysed by SLCO1B1, LTC4Sextracellular space, cytosolOne of 8 routes

• L-asparagineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• glutathione disulfideReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 13 routes

• taurolithocholate 3-sulfateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes