Loading the page.
Proteins/UNIPROT:O43837
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers..
Function from UniProtKB (O43837), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
62 statements
62 statements · 4 reference databases · Subject: IDH3B · Sources: Hetionet, Human-GEM, Reactome, WikiPathways
1 reaction
isocitric acid+NAD(+)2-oxoglutarate(2-)+carbon dioxide+NADH(2-)
Catalysed by IDH3B & IDH3A & IDH3G
Reaction pageLeft to rightBalancedEC 1.1.1.41mitochondrial matrix
Human-GEM MAR03957CC BY 4.0Reference data
2 names
Resolves to: IDH3B