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Proteins/UNIPROT:Q9H6U8
Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, catalyzes the addition of the seventh and ninth alpha-1,2-linked mannose residues to Man(6)GlcNAc(2)-PP-dolichol and Man(8)GlcNAc(2)-PP-dolichol respectively..
Function from UniProtKB (Q9H6U8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
50 statements
50 statements · 3 reference databases · Subject: ALG9 · Sources: Hetionet, Reactome, WikiPathways
4 reactions
MAM01734r+MAM01896rMAM01733r+MAM01897r+proton
Catalysed by DPM1 & DPM2 & DPM3 or ALG9
Reaction pageLeft to rightBalancedEC 2.4.1.259endoplasmic reticulum
Human-GEM MAR07275CC BY 4.0Reference data
MAM01734r+MAM01898rMAM01733r+MAM01867r+proton
Catalysed by ALG9
5 names
Resolves to: ALG9
Human-GEM MAR07277CC BY 4.0Reference data
an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol+a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphatean alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by ALG9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:29531CC BY 4.0Reference data
an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol+a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphatean alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by ALG9
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:29539CC BY 4.0Reference data